目的 觀察銀杏內(nèi)酯注射液治療缺血性腦卒中的療效，并觀察銀杏內(nèi)酯注射液在控制相關(guān)危險(xiǎn)因素方面的治療特點(diǎn)。方法 選擇缺血性腦卒中患者3 036例進(jìn)行非對照、開放式、多中心臨床研究，在基礎(chǔ)治療上使用銀杏內(nèi)酯注射液10 mL/次，0.9%氯化鈉注射液或5%葡萄糖注射液250 mL稀釋，靜脈滴注，每天1次，連續(xù)使用14 d。采用美國國立衛(wèi)生研究院卒中量表（NIHSS）觀察神經(jīng)功能缺損程度，采用改良Rankin量表觀察患者日常生活能力狀態(tài)（病殘程度），評價(jià)臨床療效。并觀察患者合并高血壓病、糖尿病、高血脂癥和高尿酸血癥4種危險(xiǎn)因素在神經(jīng)功能、病殘程度和臨床療效的差異。結(jié)果 銀杏內(nèi)酯注射液能明顯改善患者的神經(jīng)功能（P<0.01），減輕病殘程度（P<0.01），臨床總有效率為65.72%；其中不合并4種危險(xiǎn)因素的腦卒中患者的臨床治療總有效率為71.9%；合并高脂血癥、高尿酸血癥、糖尿病腦卒中患者的臨床治療總有效率分別為74.74%、75.00%、70.05%，與不合并危險(xiǎn)因素組臨床有效率基本一致；合并高血壓、3種疾病和4種疾病的臨床療效相對較差，有效率分別是63.36%、42.86%和59.42%，與其他組比較有顯著性差異（P<0.01）。結(jié)論 銀杏內(nèi)酯注射液治療缺血性腦卒中具有較好療效，其在控制缺血性腦卒中患者的危險(xiǎn)因素上具有良好的治療特點(diǎn)。

Objective To observe the clinical effects of Ginkgolide Injection on ischemic stroke, and study therapeutic features of ginkgolide on controlling the risk factors.Methods A total of 3 036 patients with ischemic stroke were studied in non-controlled, open, and multi-center clinical studies. All patients were given Ginkgolide Injection with 10 mL+0.9% NS/5% GS 250 mL, once daily for 14 d. The clinical efficacy of neurological funcfiondeicitsscale and daily life state was evaluated by comparing the former NIHSS scores and modified Rankin scale score with that after given treatment, respectively. The differences in neurological function, degree of disability and clinical efficacy of patients with four different risk factors:hypertension, diabetes, hyperlipidemia, and hyperuricemia were observed.Results Ginkgolide Injection can significantly improve the neurologic function of patients (P < 0.01) and reduce the degree of disability (P < 0.01), and the total clinical efficiency was 65.72%.The clinical efficiency of stroke patients without four kind of risk factors was 71.9%. The clinical efficiency of stroke patients with hyperlipidemia, hyperuricemia, and diabetic was 74.74%, 75%, and 70.05%, respectively, and was basically in line with that of stroke patients without any risk factor. The clinical efficiency of stroke patients with hypertension, three and four kinds of disease was 63.36%, 42.86%, and 59.42%, respectively, and was significantly different with that of stroke patients without any risk factor (P < 0.01).Conclusion Ginkgolide Injection has a positive effect on ischemic stroke with good therapeutic features on controlling the risk factors.