目的 研究中藥復(fù)方糖復(fù)康寧提取物2糖尿病模型大鼠的降血糖作用。方法 分別以遺傳性ZDF模型大鼠和鏈脲佐菌素（STZ）聯(lián)合高糖高脂飼料誘導(dǎo)的SD大鼠為此次研究的2型糖尿病模型動物，ig給予低、高劑量（5.0、10.0 g生藥/kg）的糖復(fù)康寧提取物，金芪降糖片（455 mg/kg）作為陽性藥，連續(xù)給藥42 d，每周測定空腹血糖、給藥第38天測定葡萄糖耐量。結(jié)果 ZDF模型結(jié)果顯示，模型組大鼠血糖值波動幅度保持在10%以內(nèi)，顯著高于對照組（P<0.01）；給藥42 d后，與模型組比較，各給藥組血糖均顯著下降（P<0.01），金芪降糖片及糖復(fù)康寧提取物低、高劑量組血糖下降率分別為（35.9±8.4）%、（22.1±11.1）%、（50.0±9.1）%；STZ模型結(jié)果顯示，模型組大鼠血糖一直維持在較高水平（21.1~21.6 mmol/L），變化幅度相對穩(wěn)定，顯著高于對照組（P<0.01）；給藥42 d后，與模型組比較，各給藥組血糖均下降，其中糖復(fù)康寧提取物低、高劑量組差異顯著（P<0.01）；金芪降糖片及糖復(fù)康寧提取物低、高劑量組血糖下降率分別為（18.6±5.7）%、（21.6±7.2）%、（51.7±20.2）%。糖復(fù)康寧提取物低、高2個劑量組血糖曲線下面積（AUC）與模型組比較均顯著下降（P<0.05、0.01）。結(jié)論 中藥復(fù)方糖復(fù)康寧對2種2型糖尿病模型均發(fā)揮顯著降糖效果。

Objective To study the hypoglycemic effect of Tangfukangning (TFKN) extracts on type 2 diabetes mellitus model.Methods Hereditary ZDF (Zucker diabetic fatty) model rats and SD model rats fed with streptozotocin (STZ) and high-sugar/high-lipid diet were applied as the type 2 diabetes animal model for the study. Two groups of model rats were treated with TFKN extracts at low and high doses (5 and 10 g raw medicine/kg) by ig administration and Jinqi Jiangtang Tablets (455 mg/kg) used as positive control drug, continuous administration for 42 d. The hypoglycemic effects of TFKN extracts on type 2 diabetes animal model were evaluated by determination of the fasting glucose for every week, and glucose tolerance was determinated at the 38th day of administration.Results The results of ZDF model showed that the fluctuation range of blood glucose in model group was less than 10%, which was significantly higher than that in control group (P < 0.01). Compared with model group, the blood glucose level of each drug group was significantly decreased after 42 days' administration (P < 0.01). The decreasing percentage of blood glucose in Jinqi Jiangtang Tablets and low and high doses of TFKN extracts groups were (22.1 ±11.1)%, (35.9 ±8.4)%, and (50.0±9.1)%, respectively. The results of STZ model showed that the blood glucose of model group rats remained at a high level (21.1-21.6 mmol/L), the amplitude of the change was relatively stable and significantly higher than that of the control group (P < 0.01). Compared with model group, the blood glucose level of each drug group was decreased after 42 days' administration, and the difference of the low and high dose group of TFKN extracts was significant (P < 0.01). The decreasing percentage of blood glucose in Jinqi Jiangtang Tablets and TFKN extracts low and high doses groups were (18.6±5.7)%, (21.6±7.2)%, and (51.7±20.2)%, respectively. The area under the curve (AUC) of blood glucose in the low and high dose group of TFKN extracts was significantly lower than that in model group (P < 0.05 and 0.01).Conclusion The hypoglycemic effect of TFKN extracts is significant effective in these two type 2 diabetes animal models.