目的 研究酒石酸美托洛爾聯(lián)合硫酸鎂治療妊娠期高血壓疾病的效果及對(duì)尿液蛋白質(zhì)的影響。方法 選擇2015年1月-2017年1月在文山州婦幼保健院診治的妊娠期高血壓患者70例，隨機(jī)分為各35例的兩組。對(duì)照組靜脈滴注硫酸鎂，每次60 mL，每10小時(shí)1次；研究組在對(duì)照組基礎(chǔ)上口服酒石酸美托洛爾片治療，初始劑量設(shè)定為每次20 mg，每天1次，然后每隔1天將劑量增加12.5 mg，最高劑量為每天150 mg。兩組均治療1個(gè)月。比較兩組的臨床有效率、新生兒結(jié)局情況（胎兒早產(chǎn)、胎兒窘迫、新生兒窒息和圍產(chǎn)兒死亡），以及HPLLP綜合征、產(chǎn)后出血、胎盤早剝等并發(fā)癥的發(fā)生率以及剖宮產(chǎn)率，并檢測(cè)兩組治療前后的尿鈣黏蛋白、24 h尿蛋白以及尿激肽原1水平。結(jié)果 研究組的有效率為94.29%，明顯高于對(duì)照組的80.00%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。研究組的不良新生兒結(jié)局（胎兒早產(chǎn)、胎兒窘迫、新生兒窒息和圍產(chǎn)兒死亡）發(fā)生率均低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；研究組的并發(fā)癥發(fā)生率（HPLLP綜合征、產(chǎn)后出血、胎盤早剝）及剖宮產(chǎn)率均低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組治療后的尿鈣黏蛋白、24 h尿蛋白以及尿激肽原1水平均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且研究組明顯低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 將酒石酸美托洛爾與硫酸鎂聯(lián)合用于妊娠期高血壓疾病的治療過(guò)程中，該方法臨床效果顯著，可有效改善母嬰結(jié)局，顯著降低尿液蛋白表達(dá)水平。

Objective To investigate the clinical effect of Betoloc combined with Magnesium Sulfate on gestational hypertensive disorders and its influence on urine protein.Methods 70 cases of gestational hypertension patients who were diagnosed and treated in our hospital from January 2015 to January 2017 were randomly divided into two groups of 35 patients. The control group received intravenous Magnesium Sulfate, 60 mL each time, one time every 10 h; the study group combined with oral metoprolol treatment. Comparing the clinical efficiency of the two groups with the outcome of the newborn (fetal preterm, fetal distress, neonatal asphyxia and perinatal death), and complications of HPLLP syndrome, postpartum hemorrhage, placental abruption and the incidence of cesarean section were compaed. The levels of urinary cadherin, 24 hours urinary protein and urinary kallikrein 1 were detected before and after treatment in the two groups.Results The effective rate of the study group was 94.29% (33/35), higher than 80.00% (28/35) (P < 0.05). The incidence of adverse neonates in the study group (fetal preterm birth, fetal distress, neonatal asphyxia and perinatal death) was lower than that in the control group (P < 0.05). The incidence of complications of the study group (HPLLP syndrome, postpartum hemorrhage, placental abruption) and cesarean section rate were lower than those in the control group (P < 0.05). The levels of urinary cadherin, 24 hours urinary protein and urinary kallikrein 1 were significantly lower in the two groups (P < 0.05), and the study group was significantly lower than that of the control group (P < 0.05).Conclusion Betoloc and Magnesium Sulfate in the process of combination for the treatment of gestational hypertension disease, clinical effect is remarkable, this method can effectively improve and outcomes, and significantly reduce the urine protein expression levels.