目的 研究艾拉莫德聯(lián)合甲氨蝶呤治療類風(fēng)濕性關(guān)節(jié)炎臨床效果。方法 選擇2015年1月-2017年11月在揭陽(yáng)市人民醫(yī)院進(jìn)行診治的60例類風(fēng)濕性關(guān)節(jié)炎患者，隨機(jī)分為兩組。對(duì)照組口服甲氨蝶呤治療，每次10 mg，每天1次；觀察組聯(lián)合口服艾拉莫德治療，每次25 mg，每天2次。兩組均治療3個(gè)月。比較兩組的臨床治療效果，并比較兩組治療前后的血清C反應(yīng)蛋白、類風(fēng)濕因子、抗環(huán)瓜氨酸肽抗體和紅細(xì)胞沉降率，以及白介素-6、淋巴細(xì)胞絕對(duì)值、免疫球蛋白G。結(jié)果 觀察組的有效率90.00%高于對(duì)照組70.00%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后兩組的血清C反應(yīng)蛋白、類風(fēng)濕因子、抗環(huán)瓜氨酸肽抗體和紅細(xì)胞沉降率均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組明顯低于對(duì)照組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后兩組的淋巴細(xì)胞絕對(duì)值、免疫球蛋白G、白介素-6均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組明顯低于對(duì)照組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組的不良反應(yīng)率相比無明顯差異。結(jié)論 艾拉莫德聯(lián)合甲氨蝶呤治療類風(fēng)濕性關(guān)節(jié)炎臨床效果顯著，是一種安全有效的治療方案。

Objective To investigate the clinical effect ofmethotrexate combined with iguratimod in the treatment of rheumatoid arthritis.Methods Selected 60 cases of patients with rheumatoid arthritis who were treated in our hospital from January 2015 to November 2017, divided into two groups randomly. The control group was treated with methotrexate, 10 mg each time, 1 times a day. The observation group was treated with oral iguratimod, 25 mg each time, 2 times a day. The clinical therapeutic effect of two groups were compared, and compared the serum C reactive protein, rheumatoid factor and anti-cyclic citrullinated peptide antibody and erythrocyte sedimentation rate, interleukin -6, LYMPH, immunoglobulin G.Results After treatment, the effective rate of the observation group was 90.00% (27/30), which was higher than 70.00% of the control group (21/30) (P < 0.05); after treatment, serum C reactive protein,, rheumatoid factor, anti-cyclic citrullinated peptide antibody and erythrocyte sedimentation rate of the two groups were significantly lower (P < 0.05), and the observation group was more obvious (P < 0.05); the levels of interleukin-6, immunoglobulin G, LYMPH in the two groups were significantly lower (P < 0.05), and the observation group was more obvious (P < 0.05). There was no significant difference in the adverse reaction rate between the two groups.Conclusion Methotrexate combined with iguratimod in the treatment of rheumatoid arthritis clinical effect is significant, is a safe and effective treatment.

揭陽(yáng)市科技計(jì)劃項(xiàng)目（2015B01003）