目的 探討雙相門冬胰島素30與地特胰島素對口服降糖藥失敗的2型糖尿?。═2DM）患者的療效及低血糖發(fā)生的影響。方法 選擇2014年1月-2017年1月南陽市宛城區(qū)第一人民醫(yī)院收治的86例口服降糖藥失敗的T2DM患者，根據(jù)入院先后順序，分為A組及B組，A組患者每日早晚腹部皮下注射1次雙相門冬胰島素30，B組每日睡前（21：00-22：00）腹部皮下注射一次地特胰島素，兩組均治療24周。觀察兩組治療前后的空腹血糖（FBG）、糖化血紅蛋白（HbAlc）及體質(zhì)量，對比兩組治療期間的血糖達標時間、低血糖事件發(fā)生率。結果 與治療前相比，兩組治療后的FBG、HbAlc均明顯下降，差異有統(tǒng)計學意義（P<0.05）；兩組治療前后組間的FBG及HbAlc對比差異無統(tǒng)計學意義。兩組治療前后及組間的體質(zhì)量指數(shù)對比均無統(tǒng)計學意義；兩組的血糖達標時間對比差異無統(tǒng)計學意義，但A組的低血糖發(fā)生率明顯高于B組，差異有統(tǒng)計學意義（P<0.05）。結論 口服降糖藥失敗后的T2DM患者應用雙相門冬胰島素30或地特胰島素，療效相當，但地特胰島素低血糖發(fā)生率較低，應用較為安全。

Objective To investigate the efficacy and hypoglycemia occurs influence of BIAsp30 and insulin detemir on T2DM who were oral hypoglycemic drugs failed.Methods 86 cases with T2DM who were Oral hypoglycemic drugs failed in our hospital from Jan. 2014 to Jan. 2017 were chosen and divided into A group (BIAsp30 group) and B group (insulin detemir). The fasting blood glucose, glycosylated hemoglobin and body mass of two groups before and after treatment were observed, the blood glucose standard time, low blood glucose incident rate of two groups in treatment were compared.Results Compared with before treatment, the FBG, HbAlc of two groups after treatment were all decreased (P < 0.05). The FBG and HbAlc of two groups before and after treatment had no significant difference. The body mass of two groups before and after treatment had no significant difference. The blood glucose standard time of two groups had no significant, while the hypoglycemia occurs of A groups were obvious higher than B group (P < 0.05).Conclusion T2DM who were oral hypoglycemic drugs failed were given BIAsp30 and insulin detemir had therapeutic equivalence, while the insulin detemir had lower hypoglycemia occurs, which was safety in clinical.