目的 系統(tǒng)評價羥考酮聯(lián)合加巴噴丁應(yīng)用中重度癌性疼痛的有效性和安全性。方法 檢索PubMed、Medline、中國期刊全文數(shù)據(jù)庫（CNKI）、維普中文科技期刊全文數(shù)據(jù)庫（VIP）、中國生物醫(yī)學(xué)全文數(shù)據(jù)庫（CBM）和萬方數(shù)據(jù)庫中關(guān)于羥考酮聯(lián)合加巴噴丁治療癌性疼痛的隨機對照研究，檢索時限為2000年1月至2017年8月。由2名研究者獨立提取數(shù)據(jù)、評價質(zhì)量，并交叉核對。采用RevMan 5.2軟件進行Meta-分析。結(jié)果 共納入10項研究，687例患者。Meta-分析結(jié)果顯示：羥考酮聯(lián)合加巴噴丁較羥考酮單用能顯著提高疼痛緩解率[OR=3.85，95%CI（2.25~6.60），P<0.000 01]和降低疼痛評分[MD=-0.83，95%CI（-0.95~-0.70），P<0.000 01]；能顯著減少羥考酮的劑量[MD=-17.10，95%CI（-20.16~-14.04），P<0.000 01]；能顯著減少便秘[OR=0.58，95%CI（0.42，0.82），P=0.002]和惡心嘔吐[OR=0.55，95%CI（0.37，0.82），P=0.003]的發(fā)生率；能顯著提高細(xì)胞免疫（CD4、CD8、CD4/CD8）和體液免疫（IgA、IgG、IgM）水平，差異均有統(tǒng)計學(xué)意義（P<0.01）。結(jié)論 羥考酮聯(lián)合加巴噴丁能顯著提高疼痛緩解率、降低疼痛評分，減少羥考酮平均日劑量，增強免疫功能，減少便秘和惡心嘔吐等不良反應(yīng)發(fā)生率，但兩組頭痛頭暈、嗜睡和尿潴留的發(fā)生率無統(tǒng)計學(xué)差異。

Objective To systematically review oxycodone oral preparation combined with gabapentin for treating moderate and severe cancer pain.Methods Databases including PubMed, Medline, CNKI, VIP, CBM, and WanFang Data were searched to collect randomized controlled trials (RCTs) about oxycodone oral preparation combined with gabapentin for moderate and severe cancer pain from January 2000 to August 2017. Two reviewers independently screened literature, extracted data, and assessed the bias risk of included studies. Then meta-analysis was conducted by RevMan 5.2 software.Results Total 687 patients of 10 RCTs were included. Meta-analysis showed that, comparison on oxycodone alone, oxycodone combined with gabapentin could significantly improve the rate of pain relief[OR=3.85, 95%CI(2.25-6.60), P < 0.000 01] and lower pain score[MD=-0.83, 95%CI(-0.95--0.70), P < 0.000 01]; Significant reduction the daily dose of oxycodone[MD=-17.10, 95%CI(-20.16--14.04), P < 0.000 01]; Significantly reduced the incidence of constipation[OR=0.58, 95%CI(0.42, 0.82), P=0.002], nausea and vomiting[OR=0.55, 95%CI(0.37, 0.82), P=0.003]; Meanwhile it could improve the level of cellular immunity (CD4, CD8, and CD4/CD8) and humoral immunity (IgA, IgG, and IgM), the difference was statistically significant (P < 0.01).Conclusion Oxycodone combined with gabapentin can significantly improve the pain relief rate, reduce pain score and average daily dose of oxycodone, enhance immune function, reduce the rate of constipation mnausea and vomiting, but will not significantly affect incidence in headache dizziness, lethargy, and urinary retention.