何首烏因其黑須發(fā)、益精髓、延年不老等補(bǔ)益作用在處方及中成藥中廣泛應(yīng)用，隨著中藥現(xiàn)代化的不斷進(jìn)展，關(guān)于何首烏及其成分的藥理研究也不斷深入，何首烏包含蒽醌類、二苯乙烯苷類、酚類、黃酮類、磷脂類等成分，關(guān)于何首烏提取物及其主要成分二苯乙烯苷類及蒽醌類藥理研究較多；具有抗衰老，降脂保肝、提高免疫力、治療骨質(zhì)疏松等作用，通過(guò)查閱檢索中英文數(shù)據(jù)庫(kù)，將何首烏及其主要化學(xué)成分藥理學(xué)作用進(jìn)行總結(jié)歸納，通過(guò)查閱古文獻(xiàn)記載何首烏傳統(tǒng)功效結(jié)合現(xiàn)代藥理學(xué)研究對(duì)何首烏及其主要化學(xué)成分的藥理作用進(jìn)行探討，為何首烏的臨床應(yīng)用及進(jìn)一步開(kāi)發(fā)研究提供思路與依據(jù)。

Polygonum multiflorum is widely used in prescriptions and proprietary Chinese medicines because of its beneficial effects such as black hair, essence of benefit, anti-aging, etc. Polygonum multiflorum contains terpenoids, stilbene glycosides, phenols, flavonoids, phospholipids, etc. Polygonum multiflorum and its main compounds have the effects of Anti-aging, lipid-lowering liver protection, improve immunity, treatment of osteoporosis and other effects. This article summarizes the pharmacological effects of Polygonum multiflorum and its major chemical constituents by consulting the Chinese and English database. By explore the pharmacological effects of Polygonum multiflorum and its main chemical constituents by examining the ancient literature records of the traditional efficacy of Polygonum multiflorum combined with modern pharmacology studies, to provide ideas and basis for the clinical application and further development of Polygonum multiflorum.

重大新藥創(chuàng)制專項(xiàng)（2015ZX09501004-003-004）