肺癌是一種常見的肺部惡性腫瘤，近年來，由于吸煙和各種環(huán)境因素的影響，肺癌的發(fā)病率和病死率均迅速上升。嚙齒類動物在肺癌的病因、有效致癌物、潛在協同效應、發(fā)病機制及新的肺癌診斷和治療研究中起重要作用。從影響實驗動物肺腫瘤反應的因素、人類和嚙齒類動物肺腫瘤的形態(tài)學差異、肺癌的分子學改變方面進行綜述，為肺腫瘤的臨床前動物實驗研究提供參考。

Lung cancer is a common malignant tumor in the human population. In recent years, with the influence of smoking and various environmental factors, the incidence and mortality of lung cancer have risen rapidly in various countries. Laboratory animals play an important role in the etiology of lung cancer, effective concentrations of carcinogens, potential synergistic effects, identification of pathogenesis, and new diagnosis and treatment of lung cancer. This article only described the factors that affect the response of lung tumors in experimental animals, the morphological differences between lung tumors in humans and rodents, and the molecular changes in lung cancer, to provide references for preclinical animal experiments of lung tumors.

山東抗體類和疫苗類生物藥物臨床前評價公共服務平臺的完善與運行（2015CXPT00001）