目的 研究肺咳停顆粒的止咳、祛痰、平喘、抗炎作用。方法 通過濃氨水誘發(fā)小鼠咳嗽模型，觀察肺咳停顆粒（0.97、1.94、3.88 g生藥/kg）止咳作用；通過小鼠酚紅分泌實驗，觀察其祛痰作用；通過卵蛋白誘發(fā)豚鼠哮喘模型，觀察其（0.59、1.18、2.36 g生藥/kg）平喘作用；通過大鼠瓊脂肉芽腫炎癥模型，觀察其（0.67、1.34、2.68 g生藥/kg）抗炎作用；通過小鼠二甲苯耳腫脹炎癥模型，觀察其抗炎作用。結(jié)果 與對照組比較，肺咳停顆粒低、中、高劑量組均能延長小鼠咳嗽潛伏期、減少2 min內(nèi)咳嗽次數(shù)；增加小鼠酚紅分泌量；延長豚鼠哮喘發(fā)作潛伏期；抑制大鼠瓊脂塊的生長和小鼠耳腫脹程度，并且呈現(xiàn)一定量效關(guān)系（P<0.05、0.01）。結(jié)論 肺咳停顆粒具有一定的止咳、祛痰、平喘、抗炎作用。

Objective To investigate the Feiketing Granules on the relieving cough, eliminating sputum, relieving asthma, and anti-inflammatory. Methods The effects by the model of mouse induced by strong ammonia, the amount of phenol red seretion by mouse, guinea pig asthmaed by egg albumin, the agar granuloma model of rat and the ear swelling model of mouse induced by xylene soiution was studied. Results Compared with the blank control group, the low-, medium-, and high-dosage group of Feiketing Granules could prolong the cough incubation period of mouse, reduce the number of cough in two minutes, increase the secretion of phenol red, increase asthma incubation period of guinea pig, decrease the weight of the agar granuloma and ear swelling, meanwhile existing the dose-effect relationship (P<0.05 and 0.01). Conclusions The results showed Feiketing Granules could relieve cough, eliminat sputum, relieve asthma, and have anti-inflammatory effect.

泰山醫(yī)學(xué)院附屬醫(yī)院青年基金（2014QN05）