目的 探討新型國產(chǎn)重組甘精胰島素注射液對1型糖尿病模型大鼠的降糖作用。方法 選擇健康SD大鼠和鏈脲佐菌素誘導(dǎo)的1型糖尿病大鼠，甘精胰島素注射液（來得時(shí)）為陽性對照藥，健康SD大鼠單次sc 2、4 IU/kg劑量的重組甘精胰島素注射液，大鼠尾靜脈采血，分別測定0 h（給藥前）及給藥后1、2、4、6、8 h空腹血糖；1型糖尿病模型大鼠連續(xù)5 d sc 4、8 IU/kg劑量的重組甘精胰島素注射液，每天分別測定給藥前（0 h）和給藥后（4 h）空腹血糖，給藥第1、5天測定給藥后1、2、4、6、8 h空腹血糖。結(jié)果 健康大鼠sc重組甘精胰島素注射液2、4 IU/kg后，血糖值在2 h下降到最低，與對照組比較差異顯著（P<0.01）；模型大鼠連續(xù)5 d sc 4、8 IU/kg重組甘精胰島素注射液，血糖于給藥后4~6 h下降至最低點(diǎn)，與模型組比較差異顯著（P<0.01）；每天給藥4 h后血糖均呈平穩(wěn)下降趨勢，與模型組比較差異顯著（P<0.01），8 IU/kg血糖值與對照組接近。結(jié)論 國產(chǎn)重組甘精胰島素注射液對1型糖尿病模型大鼠有較好的降糖效果，與同劑量陽性藥降糖效果相當(dāng)。

Objective To explore the hypoglycemic effect of novel domestic recombinant insulin glargine injection on type 1 diabetic model rats. Methods Healthy SD rats and type I diabetic model rats induced by streptozotocin were used as model animals. The insulin glargine injection (Lantus) were used as the positive control drug. Healthy SD rats were sc injected with recombinant insulin glargine injection at two doses of 2 and 4 IU/kg for one time. Blood samples were taken from the tail vein of rats, the blood glucose values of 0 h and 1, 2, 4, 6, and 8 h were determined after administration. Type 1 diabetic model rats were sc injected with recombinant insulin glargine injection at two doses of 4 and 8 IU/kg for 5 d. Fasting blood glucose was measured daily before and after administration (4 h). Fasting blood glucose was measured at 1, 2, 4, 6, and 8 h after administration for days 1 and 5. Results After injected with 2 and 4 IU/kg, the blood glucose level was the lowest level in 2 h, which was significantly different compared with control group (P<0.01). After sc injection of recombinant insulin glargine injection at two dose of 4 and 8 IU/kg in the model rats, the blood sugar decreased to the lowest point after 4-6 h, which was significantly different compared with model group (P<0.01), and the blood glucose decreased steadily 4 h after administration per day, and was significantly different from the model group (P<0.01), and the blood sugar of 8 IU/kg group was close to control group. Conclusion The domestic recombinant insulin glargine injection have good effect on hypoglycemic in rats with type 1 diabetes.