目的 分析胎盤多肽注射液聯(lián)合mFOLFOX6方案對結直腸癌患者術后血脂及不良反應的影響。方法 選取云南省第三人民醫(yī)院2015年3月-2017年3月收治的150例結腸癌患者，按照隨機數(shù)字表法分為觀察組、對照組，各75例，均行腹腔鏡下結直腸癌根治術治療，術后使用mFOLFOX6方案行輔助化療，化療方案每周期持續(xù)2周，患者共接受6個周期化療；觀察組在上述治療方案的基礎上，化療期間加用胎盤多肽注射液靜脈滴注。比較兩組患者化療1周期前后血脂變化、化療期間不良反應發(fā)生情況及化療結束后近期療效，總結胎盤多肽注射液對患者術后血脂及不良反應的影響。結果 與化療前1 d相比，兩組患者化療14 d后三酰甘油（TG）、低密度脂蛋白膽固醇（LDL-C）、高密度脂蛋白膽固醇（HDL-C）均升高，對照組化療14 d后TG、LDL-C、HDL-C均高于觀察組，差異有統(tǒng)計學意義（P<0.05）?；熃Y束后，觀察組、對照組臨床總有效率分別為45.33%、42.67%，組間比較差異無統(tǒng)計學意義。化療期間，觀察組Ⅲ~Ⅳ度惡心/嘔吐、外周神經毒性發(fā)生率低于對照組，其Ⅰ~Ⅱ度及Ⅲ~Ⅳ度口腔黏膜炎發(fā)生率均低于對照組，差異有統(tǒng)計學意義（P<0.05）。結論 將胎盤多肽注射液聯(lián)合mFOLFOX6方案用于結腸癌術后輔助化療，能夠在保證化療效果的基礎上弱化化療藥物對脂質代謝的影響、降低不良反應發(fā)生率，從而有效提高化療安全性。

Objective To analyze the effects of placental polypeptide injection combined with mFOLFOX6 on blood lipid and adverse reactions in patients with colorectal cancer after operation. Methods 150 cases of colon cancer patients in our hospital from March 2015 to March 2017 were randomly divided into observation group and control group, each 75 cases. All patients underwent laparoscopic radical resection for colorectal cancer, and the mFOLFOX6 regimen was used for adjuvant chemotherapy. The observation group received intravenous injection of placental polypeptide injection on the basis of the above treatment regimen during chemotherapy. The changes of blood lipid before and after chemotherapy, adverse reactions during chemotherapy and the short-term efficacy after chemotherapy were compared between the two groups. The effects of placental polypeptide injection on the blood lipids and adverse reactions were summarized. Results Compared with the 1 d before chemotherapy, the TG, LDL-C and HDL-C were elevated of the two groups after 14 d chemotherapy, the TG, LDL-C, HDL-C of the control group were higher than the observation group after 14 d chemotherapy, the difference was statistically significant (P<0.05). After chemotherapy, the total effective rate of the observation group and the control group was 45.33% and 42.67%, and there was no significant difference between the two groups. During chemotherapy, the Ⅲ-IV degree of nausea/vomiting, peripheral neurotoxicity rate of the observation group were lower than the control group, the I-Ⅱ and Ⅲ-IV degree of oral mucositis were lower than the control group, the difference was statistically significant (P<0.05). Conclusion The placenta polypeptide injection combined with mFOLFOX6 regimen for adjuvant chemotherapy after resection of colorectal cancer, can ensure the effect of chemotherapy on the basis of weakening effect of chemotherapeutic drugs on lipid metabolism, and reducing the incidence of adverse reactions, so as to effectively improve the safety of chemotherapy.