膿毒癥是由于感染而引起的全身炎癥反應綜合征。血必凈注射液是基于"菌毒炎并治"理念創(chuàng)制的中藥復方制劑，與其他藥物聯(lián)合應用，在臨床上治療膿毒癥效果確切。綜述血必凈注射液治療膿毒癥藥理作用機制的研究進展，包括蛋白家族（如高遷移率族蛋白、中性粒細胞翻譯控制腫瘤蛋白、肌紅蛋白等）、細胞因子（炎性因子、血管內(nèi)皮因子）和生物酶類（基質(zhì)金屬蛋白酶-9、誘導型一氧化氮合酶），以期更好地應用該藥提供依據(jù)。

Sepsis is a response syndrome caused by infection and systemic inflammatory. Xuebijing Injection is a Chinese materia medica compound formula which is based on "the principle of bacterial infection and treatment". It is used in combination with other drugs to treat sepsis with its definite effect. This review summarizes the research progress of pharmacological mechanism of Xuebijing Injection in the treatment of sepsis, such as protein family (high mobility group box protein, neutrophil translation controls tumor proteins, MYO), cell factor (inflammatory factor, vascular endothelial growth factor), and biological enzymes (MMP-9, iNOS), in order to provide a basis for better application of this medicine.