病理學(xué)診斷中特殊染色具有重要的應(yīng)用價(jià)值，通過長(zhǎng)期的改進(jìn)與創(chuàng)新特殊染色能夠有針對(duì)性地對(duì)組織成分進(jìn)行染色，使組織病理學(xué)評(píng)價(jià)更加完善精確。非臨床藥物評(píng)價(jià)中常用的特殊染色法有結(jié)締組織染色的Masson三色染色法、肌肉染色的磷鎢酸蘇木素染色法、糖原染色的過碘雪夫染色法、脂質(zhì)類染色的油紅O染色法、色素類染色的Masson-Fontana染色法，以及神經(jīng)組織染色和病理沉著物染色等，綜述特殊染色的主要內(nèi)容及應(yīng)用中注意事項(xiàng)。

Special staining possesses important application value in pathological diagnosis. Owing to the perennial improvement and innovation of staining methods, special staining has already been used to stain the specific tissue components, which greatly improves histopathological evaluation and makes the results of assessments more precise. Many special staining methods are commonly used in the evaluation of nonclinical drugs, such as Masson trichrome staining of connective tissues, Mallory phosphotungstic acid hematoxylin staining of muscles, periodic acid-Schiff staining of glycogen, Oil red O staining of lipids, Masson-Fontana staining of pigments, other staining of nervous tissues and pathological deposits, et al. This review summarizes the methods and application of special staining.