目的 研究頸內(nèi)動(dòng)脈系統(tǒng)腦梗死患者給予注射用丹參多酚酸治療的臨床療效，及其對(duì)血液指標(biāo)的影響。方法 從保定市第一中心醫(yī)院2016年1月1日-2017年6月1日收治的頸內(nèi)動(dòng)脈系統(tǒng)腦梗死患者中選取100例作為研究對(duì)象，隨機(jī)分為2組，各50例。對(duì)照組給予常規(guī)治療，觀察組在常規(guī)治療基礎(chǔ)上給予注射用丹參多酚酸130 mg溶于250 mL 0.9%氯化鈉注射液中靜脈滴注，1次/d，均14 d為1個(gè)療程。比較治療后兩組患者的療效、凝血酶原時(shí)間（PT）、活化部分凝血活酶時(shí)間（APTT）、纖維蛋白原（FIB）、D-二聚體（D-D）、低密度脂蛋白膽固醇（LDL-C）、三酰甘油（TG）、總膽固醇（TC）、C反應(yīng)蛋白（CRP）、同型半胱氨酸（Hcy）、基質(zhì)金屬蛋白酶9（MMP9）、白介素-6（IL-6）等指標(biāo)的變化。結(jié)果 治療后觀察組總有效率88.00%顯著高于對(duì)照組76.00%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組Hcy、CRP、FIB、D-D、LDL-C、TG、TC、IL-6、MMP9均顯著低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；觀察組HDL-C顯著高于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組不良反應(yīng)總發(fā)生率12.00%與對(duì)照組不良反應(yīng)總發(fā)生率14.00%無(wú)明顯差異。結(jié)論 注射用丹參多酚酸治療頸內(nèi)動(dòng)脈系統(tǒng)腦梗死療效顯著，并可有效改善血脂、血凝情況，降低炎性因子水平，且安全性好。

Objective To study the clinical efficacy of Salvianolic Acids for Injection (SAFI) on cerebral infarction in the carotid artery system, and evaluate its safety and effects on blood indexes. Methods A total of 100 cases of carotid artery systemcerebral infarction patients in Baoding No.1 Central Hospital from January 1st, 2016 to June 1st, 2017 were selected as the research object, patients were randomly divided into two groups, 50 cases in the control group were given routine treatment, 50 cases in the observation group were given SAFI 130 mg of which was dissolved in 250 mL of 0.9% sodium chloride injection, and intravenous infusion was given once a day, for 14 d as one course. After treatment, curative effect, blood lipid, blood coagulation, C reactive protein (CRP), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-Dinmei (D-D), LDL cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC), homocysteine (Hcy), MMP9 (matrix metalloproteinase 9) and IL-6 (interleukin-6) of the two groups were compared. Results After treatment, the total effective rate of the observation group 88% was significantly higher than that of the control group 76% (P<0.05). There was no significant difference between PT, APTT of the observation group and the control group (P>0.05); Hcy, CRP, FIB, D-D, LDL-C, TG, TC, IL-6, and MMP9 of the observation group were significantly lower than those of the control group (P<0.05); HDL-C of the observation group were significantly higher than those of the control group (P<0.05). There had no significant difference between total incidences of adverse reactions of the observation group 12% and the control group 14%. Conclusion The SAFI for the treatment of cerebral infarction of internal carotid artery system has significant curative effect, and can effectively improve blood lipid, blood coagulation situation, reduce levels of inflammatory factors, and show good safety.

河北省中醫(yī)藥管理局項(xiàng)目（2018433）