目的 探討高壓氧療聯(lián)合注射用丹參多酚酸治療腦梗死的療效及對患者血液流變學(xué)的影響。方法 選取2016年1月-2018年2月周口市中心醫(yī)院收治的腦梗死患者80例，隨機分為兩組，兩組患者均給予降血脂、降血壓、改善微循環(huán)、降低顱內(nèi)壓、抗凝、抗血小板聚集及腦神經(jīng)保護藥等常規(guī)治療。對照組應(yīng)用注射用丹參多酚酸，將100 mg注射用丹參多酚酸與250 mL 0.9%的NaCl注射液混合后為患者靜脈滴注，1次/d；觀察組應(yīng)用高壓氧療（氧療壓力為0.25~0.30 MPa，時間為3min；氧濃度為80%~90%，溫度為18~25℃）聯(lián)合注射用丹參多酚酸；1個療程為14 d，連續(xù)治療4個療程。比較兩組患者血細胞比容、全血低切黏度、全血高切黏度、血漿黏度、治療療效、巴塞爾（Barthel）指數(shù)、神經(jīng)功能（CSS）分值、神經(jīng)功能缺損（NIHSS）分值以及血清腫瘤壞死因子-α（TNF-α）、白細胞介素-6（IL-6）、神經(jīng)生長因子（NGF）濃度。結(jié)果 治療后兩組患者血細胞比容、全血低切黏度、全血高切黏度、血漿黏度均顯著降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組各指標(biāo)均顯著低于對照組（P<0.05）。觀察組治療療效顯著優(yōu)于對照組（P<0.05）。治療后兩組患者Barthel指數(shù)明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組顯著高于對照組（P<0.05）。治療后兩組患者CSS分值、NIHSS分值明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組顯著低于對照組（P<0.05）。治療后兩組患者血清TNF-α、IL-6濃度均明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組顯著低于對照組（P<0.05）。治療后兩組患者血清NGF濃度均明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組顯著高于對照組（P<0.05）。結(jié)論 高壓氧療聯(lián)合注射用丹參多酚酸治療腦梗死療效確切。

Objective To explore the efficacy of hyperbaric oxygen therapy combined with Salvianolic Acids for Injection in the treatment of cerebral infarction and its effect on the hemorheology of patients. Methods Tatolly 80 cases of cerebral infarction patients admitted to our hospital from January 2016 to February 2018 were selected and randomly divided into two groups. Patients in control group were treated with Salvianolic Acids for Injection, Salvianolic Acids for Injection was mixed with 250 mL 0.9% NaCl injection for intravenous drip once a day. One course of treatment was 14 days, and four consecutive courses of treatment were given. Patients in research group was treated with hyperbaric oxygen therapy combined with Salvianolic Acids for Injection. Compare two groups of patients with hematocrit, whole blood low shear viscosity, whole blood high shear viscosity, plasma viscosity, treatment efficacy, Barthel index, neurological (CSS) score, nerve function defect (NIHSS) score, serum tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6), the nerve growth factor (NGF) concentration. Results The blood cell volume, total blood viscosity, total blood viscosity and plasma viscosity of study group were lower than those of control group (P<0.05). The curative effect of study group was better than that of control group (P<0.05). The Barthel index of study group was higher than that of control group (P<0.05). The CSS and NIHSS score of study group was lower than that of control group (P<0.05). TNF-α and IL-6 concentrations in study group were lower than those in control group (P<0.05). NGF concentration in study group was higher than that in control group (P<0.05). Conclusion Hyperbaric oxygen therapy combined with Salvianolic Acids for Injection is effective in the treatment of cerebral infarction.