目的 觀察注射用丹參多酚酸對(duì)缺血性腦卒中患者血漿同型半胱氨酸（Hcy）、血清D-二聚體、高敏C-反應(yīng)蛋白（hs-CRP）水平和血液流變參數(shù)的影響，并監(jiān)測(cè)不良反應(yīng)發(fā)生情況。方法 收集2016年3月-2017年8月許昌市中心醫(yī)院的神經(jīng)內(nèi)科缺血性腦卒中住院病患，共118例。采用隨機(jī)平行法將患者分為對(duì)照組、觀察組，對(duì)照組采用常規(guī)治療方法，包括盡早口服阿司匹林150~300 mg/d，并輔以血壓調(diào)控、血糖控制以及并發(fā)癥管理；觀察組在對(duì)照組治療基礎(chǔ)上聯(lián)合注射用丹參多酚酸0.13 g，用0.9%氯化鈉注射液250 mL溶解后靜脈滴注，每天1次；療程均為14 d。觀察臨床療效和不良反應(yīng)發(fā)生情況，測(cè)評(píng)治療前后血漿Hcy、血清D-二聚體、hs-CRP水平和血液流變參數(shù)。結(jié)果 觀察組治療有效率為88.14%，與對(duì)照組的72.88%比較差異顯著（P<0.05）。治療后兩組血漿Hcy、血清D-二聚體、hs-CRP水平均較治療前均顯著下降（P<0.05），且觀察組各指標(biāo)均顯著低于對(duì)照組（P<0.05）。治療后兩組血漿黏度、全血高切黏度、血小板聚集率、全血低切黏度均較治療前顯著降低（P<0.05），且觀察組各指標(biāo)均顯著低于對(duì)照組（P<0.05）。兩組均未出現(xiàn)嚴(yán)重不良反應(yīng)。結(jié)論 注射用丹參多酚酸改善缺血性腦卒中患者Hcy、D-二聚體、hs-CRP水平以及血液流變參數(shù)，提高臨床治療有效率，并且表現(xiàn)出較高的安全性。

Objective To observe the effects of Salvianolic Acid for Injection on Hcy, D-dimer, hs-CRP levels and hemorheological parameters in patients with ischemic stroke, and to monitor the occurrence of adverse reactions. Methods From March 2016 to August 2017, a total of 118 patients were hospitalized from patients with neurological hemorrhagic stroke in Central Hospital of Xuchang City. Patients were divided into observation and control group by random parallel method. The patients in control group received routine treatment, including oral aspirin 150-300 mg/d as early as possible, supplemented by blood pressure control, blood sugar control and complication management. The patients in observation group was treated with salvianolic acid 100 mg for injection and 0.9% sodium chloride injection 250 mL for intravenous drip once a day on the basis of the control group. The course of treatment is 14 d. The clinical efficacy and adverse reactions were observed, and plasma Hcy, serum D-dimer, hs-CRP levels and blood rheology parameters were measured before and after treatment. Results After treatment, the levels of plasma Hcy, serum D-dimer and hs-CRP in two groups were significantly decreased compared with before treatment (P<0.05), and the indexes in observation group were significantly lower than those in control group (P<0.05). After treatment, the plasma viscosity, whole blood high-viscosity, platelet aggregation rate and whole blood low-cut viscosity of two groups were significantly lower compared with before treatment (P<0.05), and the indexes of observation group were significantly lower than control group, showing statistically significant difference (P<0.05). The effective rate of treatment in observation group was 88.14%, which was significantly different from control group (72.88%) (P<0.05). No serious adverse reactions occurred in either group. Conclusion Salvianolic Acid for Injection has a certain effect on the improvement of ischemic stroke. In the clinical study, all patients evaluated improved blood rheological parameters, and improved serum Hcy, D-dimer, and hs-CRP. The clinical treatment efficiency of patients improved and showed higher security.