目的 評價(jià)注射用丹參多酚酸治療腦梗死急性期患者的療效及對超敏C反應(yīng)蛋白（hs-CRP）和血液流變的影響。方法 將80例腦梗死急性期患者依據(jù)隨機(jī)數(shù)字表法分為觀察組與對照組，每組40例。對照組采用常規(guī)西藥治療，觀察組在對照組治療基礎(chǔ)上加用注射用丹參多酚酸0.13 g用0.9%氯化鈉注射液稀釋，靜脈滴注1次/d。兩組療程均為14 d。比較兩組治療后療效變化，治療前后NIHSS評分、細(xì)胞炎癥因子和血流變學(xué)水平的變化，并記錄藥物不良反應(yīng)。結(jié)果 治療后，觀察組總有效率95.0%，高于對照組的77.5%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；兩組NIHSS評分均較治療前下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組下降幅度高于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療前，兩組患者h(yuǎn)s-CRP水平，血漿黏度、血沉、全血黏度高切、全血黏度低切水平相似，差異無統(tǒng)計(jì)學(xué)意義；治療后，兩組患者血清hs-CRP水平、血漿黏度、血沉、全血黏度高切、全血黏度低切水平均降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；但觀察組患者的降低幅度明顯于對照組，差異比較有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療過程中，兩組患者無明顯的藥物不良反應(yīng)。結(jié)論 注射用丹參多酚酸治療腦梗死急性期患者療效明確，可以降低hs-CRP水平和改善血液流變學(xué)，且比較安全。

Objective To investigate the effect of Salvianolic Acids for Injection (SAFI) in the treatment of patients with acute cerebral infarction and its effect on hs-CRP and hemorheology. Methods A total of 80 patients with acute cerebral infarction were randomly divided into treatment group (n=40)and control group (n=40). The patients in the control group were treated with conventional western medicine, and the patients in the treatment group received SAFI 0.13 g dissolved in 250 mL of 0.9% sodium chloride injection based on the treatment of control group, intravenous drip once a day. The course of treatment was 2 weeks in two groups. The therapeutic effects of two groups were compared. The changes of NIHSS score, cell cytokines and hemorheology levels before and after treatment and adverse reactions were also observed and recorded. Results After the treatment, the total effective rate of the treatment group (95.0%) was significantly higher than that of control group's (77.5%) (P<0.05). The NIHSS scores of the two groups were lower than those before treatment, and the NIHSS score of the treatment group was lower than the control group's (P<0.05). the serum hs-CRP level, plasma viscosity, ESR, high shear rate and low shear rate of whole blood viscosity in the two groups were all decreased, but the decrease of the observation group was significantly higher than that of the control group (P<0.05). During the treatment, there were no obvious adverse drug reactions in the two groups. Conclusion The curative effect of Salvianolic Acids for Injection in the treatment of acute cerebral infarction is confirmed, it can reduce the level of hs-CRP and improve hemorheology, and it is relatively safe.