目的 探討注射用丹參多酚酸在治療腦小血管病時對患者認(rèn)知功能障礙的影響。方法 選擇80例腦小血管病患者，隨機(jī)分為兩組，對照組給予常規(guī)治療方案，觀察組在常規(guī)治療方案的基礎(chǔ)上給予注射用丹參多酚酸治療。療程均為2周，80例研究對象在治療前后均進(jìn)行MoCA評分，并觀察治療中的不良反應(yīng)。結(jié)果 治療前，兩組MoCA評分及MMSE評分無差異；對照組治療后的MoCA評分及MMSE評分較治療前提高，但差異無統(tǒng)計學(xué)意義；觀察組治療后的MoCA評分及MMSE評分較治療前提高，差異有統(tǒng)計學(xué)意義（P<0.05）；觀察組治療后的MoCA評分及MMSE評分較對照組改善顯著，兩組間比較差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組治療過程中均無明顯不良反應(yīng)。結(jié)論 注射用丹參多酚酸可有效改善腦小血管病患者的認(rèn)知功能障礙，并且安全性良好。

Objects To investigate the effect of Salvianolic Acids for Injection on cognitive dysfunction in patients with cerebral small vessel disease. Methods Eighty patients with cerebral small vessel disease were randomly divided into two groups. The control group received a conventional treatment plan. The treatment group was given Salvianolic Acids for Injection on the basis of the conventional treatment plan. The treatment was two weeks. 80 patients underwent MoCA score before and after treatment, and observe the adverse reactions in the treatment. Results There was no difference in MoCA scores between the two groups before treatment. After treatment, the MoCA score of the control group was higher than that of the control group, but there was no significant difference, and the treatment was ineffective. After treatment, the MoCA score of the observation group was higher than that of the control group (P=0.025). After treatment, the MoCA score of the two groups was different (P=0.001). After treatment, the MoCA score of the observation group improved significantly compared with that of the control group. Conclusions Salvianolic Acids for Injection can effectively improve cognitive dysfunction in patients with cerebral small vessel disease and has good safety.