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[摘要]
目的 研究注射用丹參多酚酸對短暫性腦缺血發(fā)作的臨床療效。方法 將大慶市中醫(yī)醫(yī)院2017年1月-2018年8月收治的短暫性腦缺血發(fā)作患者80例,隨機分成觀察組與對照組,各40例。對照組采取口服鹽酸氟桂利嗪聯(lián)合阿司匹林的常規(guī)治療,觀察組在常規(guī)治療基礎(chǔ)上加用注射用丹參多酚酸0.13 g用0.9%氯化鈉注射液250 mL稀釋,靜脈滴注1次/d。兩組療程均為14 d,觀察臨床療效。采用經(jīng)顱多普勒超聲儀對兩組患者在治療前后大腦前動脈(ACA)、大腦中動脈(MCA)及大腦后動脈(PCA)腦血管的血流速度進行檢測。結(jié)果 觀察組治療總有效率為92.5%,對照組的總有效率為70.0%,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療后兩組的ACA、MCA、PCA峰值流速均較治療前明顯改善,且觀察組的改善程度優(yōu)于對照組的(P<0.05)。結(jié)論 丹參多酚酸能改善腦部血流動力學(xué),有效改善腦缺血癥狀,對短暫性腦缺血發(fā)作有良好的療效。
[Key word]
[Abstract]
Objective To explore the clinical effect of Salvianolic Acids for Injection (SAFI) on transient ischemic attack. Methods A total of 80 patients with transient ischemic attack in Daqing Traditional Chinese Medicine Hospital from January 2017 to August 2018, were randomly divided into treatment group and control group, 40 cases in each group. The control group was treated with flunarizine hydrochloride combined with aspirin. The treatment group was given 0.13 g SAFI dissolved in 0.9% sodium chloride injection 250 mL by intravenous drip once a day based on the treatment of the control group. The course of treatment was 14 d in two groups, and the therapeutic effects of two groups were compared. Transcranial Doppler ultrasonography (TCD) was used to detect the cerebral blood flow velocity before and after treatment in two groups. TCD was used to determine the three main cerebrovascular response to cerebral blood flow:anterior cerebral artery (ACA), middle cerebral artery (MCA) and posterior cerebral artery (PCA). Results The total effective rate was 92.5% in the treatment group and 70.0% in the control group. The difference between the two groups was statistically significant (P<0.05). After treatment, the improvement of peak velocity of ACA, MCA and PCA in two groups were better than those before treatment(P<0.05), and treatment group was better than that in control group (P<0.05). Conclusion SAFI can improve cerebral hemodynamics and cerebral ischemic symptoms, and has a good therapeutic effect on transient ischemic attack.
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