目的 觀察注射用丹參多酚酸治療急性期腦梗死的臨床療效及安全性。方法 124例急性期腦梗患者隨機分為觀察組、對照組，各62例。對照組給予抗血小板聚集、調(diào)控血脂、改善循環(huán)、營養(yǎng)神經(jīng)、控制血壓血糖及對癥支持治療腦梗死的藥物治療，必要時應用脫水劑；觀察組在對照組治療基礎(chǔ)上加用注射用丹參多酚酸0.13 g溶于0.9%的氯化鈉溶液250 mL緩慢靜脈滴入，1次/d，共14 d。比較兩組治療前后美國國立衛(wèi)生研究院卒中量表（NIHSS）評分、日常生活能力量表（Barthel Index，BI）評分改善的情況，患者治療前后分別進行肝、腎功能化驗，評價其安全性。結(jié)果 觀察組與對照組治療前NIHSS評分及BI評分比較差異沒有統(tǒng)計學意義；治療后，兩組患者NIHSS評分顯著降低，BI評分顯著升高，治療前后差異均具有統(tǒng)計學意義（P<0.05）；治療后，與對照組比較，觀察組患者BI評分顯著升高，NIHSS評分顯著降低，差異具有統(tǒng)計學意義（P<0.05）。治療后，觀察組患者的總有效率是79.03%，顯著高于對照組的45.16%，差異具有統(tǒng)計學意義（P<0.05）。兩組患者在用藥期間未出現(xiàn)嚴重不良反應。結(jié)論 注射用丹參多酚酸可明顯改善急性腦梗死患者的神經(jīng)功能，提高患者的生活質(zhì)量，是治療急性腦梗死安全有效的方法。

Objective To observe the clinical efficacy and safety of Salvianolic acid for Injection in the treatment of acute cerebral infarction. Methods Tatolly 124 patients with acute cerebral infarction were randomly divided into observation group and control group (n=62). Patiens in control group was given anti-platelet aggregation, regulating blood lipid, improving circulation, nourishing nerve, controlling blood pressure, blood sugar and symptomatic support to treat cerebral infarction, and dehydrating agent was used when necessary. Patiens in observation group was given salvianolic acid 0.13 g dissolved in 0.9% sodium chloride solution 250 mL intravenously, once a day for 14 days. NIHSS and Barthel Index score of the two groups were compared before and after treatment. Liver and kidney function tests were conducted before and after treatment to evaluate the safety of the two groups. Results There was no significant difference in NIHSS score and BI score between the observation group and the control group before treatment; after treatment, the NIHSS score of the two groups decreased significantly, BI score increased significantly, and the difference was statistically significant before and after treatment (P<0.05); after treatment, compared with the control group, the BI score of the observation group increased significantly, and the NIHSS score decreased significantly (P<0.05). After treatment, the total effective rate of the observation group was 79.03%, which was significantly higher than 45.16% of the control group (P<0.05). There were no serious adverse reactions in the two groups. Conclusion Salvianolic Acid for Injection can significantly improve the neurological function and quality of life of patients with acute cerebral infarction, which is a safe and effective method for the treatment of acute cerebral infarction.