注射用丹參多酚酸是以唇形科丹參藥材為原料，采用現(xiàn)代先進(jìn)工藝提取、分離其水溶性酚酸類有效成分研制而成的新一代中藥注射劑。藥理研究表明，丹參多酚酸對(duì)缺血性腦損傷具有抗炎、抗氧化應(yīng)激、神經(jīng)營養(yǎng)、再生和保護(hù)的作用，同時(shí)能夠減輕心肌缺血損傷和糖尿病腎損傷。在臨床上主要用于中風(fēng)病（輕中度腦梗死）恢復(fù)期瘀血阻絡(luò)證的治療，近年來也逐步拓展應(yīng)用到了急性腦梗死、呼吸綜合征等方面的治療。主要對(duì)注射用丹參多酚酸上市以來的藥理作用、臨床應(yīng)用及安全性評(píng)價(jià)加以綜述，為進(jìn)一步開展基礎(chǔ)試驗(yàn)提供研究線索，為臨床推廣應(yīng)用提供參考依據(jù)。

Salvianolic Acids for Injection (SAFI) using Salvia miltiorrhiza as raw material is a new generation of traditional Chinese medicine injection which is made by modern advanced technology to extract and separate the effective components of water-soluble phenolic acids. Modern pharmacological research shows that SAFI has the pharmacological effects of anti-inflammatory, antioxidative stress, neurotrophic, regeneration and protective effects on ischemic brain injury. At the same time, it can reduce myocardial ischemia and diabetic kidney injury. It is mainly used for the treatment of stroke (mild to moderate cerebral infarction). In recent years, it has also been gradually extended to the treatment of acute cerebral infarction and respiratory syndrome. Pharmacological action, clinical application, and safety evaluation of SAFI were reviewed in this article, to provide a clue for the further development of the basic research and a reference for the clinical application.

天津市中藥注射劑關(guān)鍵技術(shù)校企協(xié)同創(chuàng)新實(shí)驗(yàn)室建設(shè)（17PTSYJC00090）