目的 探討丙種球蛋白聯(lián)合α1b干擾素治療兒童EB病毒感染的效果。方法 選擇佛山市南海區(qū)婦幼保健院2015年1月-2018年12月收治的80例EB病毒感染患兒，根據(jù)隨機數(shù)字表法，將所有患兒分為觀察組（45例）及對照組（45例），兩組患兒均給予抗感染、補液等對癥治療，對照組在對癥治療基礎(chǔ)上給予α1b干擾素，觀察組在對照組基礎(chǔ)上加用丙種球蛋白。對比兩組患兒的治療效果、臨床癥狀改善時間、EB-DNA轉(zhuǎn)陰率、患兒治療前后的T淋巴細(xì)胞亞群水平及治療過程中不良反應(yīng)。結(jié)果 觀察組的總有效率為97.8%，對照組為82.2%，觀察組的總有效率顯著高于對照組（P<0.05）。觀察組的體溫下降時間、淋巴結(jié)消退時間、咽部體征消失時間、異型淋巴細(xì)胞恢復(fù)正常時間均顯著低于對照組（P<0.05）。治療后，兩組患兒的CD4⁺、CD4⁺/CD8+顯著上升，CD8+顯著下降（P<0.05）；且觀察組改變幅度顯著優(yōu)于對照組（P<0.05）；觀察組的EB-DNA轉(zhuǎn)陰率顯著高于對照組（P<0.05）。兩組治療過程中不良反應(yīng)發(fā)生情況無統(tǒng)計學(xué)差異。結(jié)論 與單獨應(yīng)用α1b干擾素相比，丙種球蛋白聯(lián)合α1b干擾素治療兒童EB病毒感染安全有效，可縮短患兒臨床癥狀改善時間，提高轉(zhuǎn)陰率及患兒免疫功能。

Objective To investigate the efficacy of α1b interferon combined with gamma globulin in treatment of children with EB virus infection. Methods 80 cases with EB virus infection from Jan. 2015 to Dec. 2018 in our hospital were chosen, who were divided to the observation group (45 cases) and control group (45 cases) according to random number table method. The children in two groups were given anti-infection, fluid and other symptomatic treatment, the control group were given atomized inhalation of alpha 1b interferon on the base of symptomatic treatment, the treatment effect, clinical symptom improvement time, EB-DNA conversion rate, T lymphocyte subsets and adverse reactions before and after treatment in two groups were compared. Results The total efficacy of observation group was higher than control group, the hypothermia time, lymph node regression time, pharyngeal signs disappearance time, and abnormal lymphocyte recovery time were all significantly lower than control group, the CD4⁺、CD4⁺/CD8⁺ of two groups were obvious higher, the CD8⁺ were obvious lower, and the changes of observation group were significantly higher than that of control group, the EB-DNA overcast rate of observation group was higher than control group, the adverse reaction of two groups had no significant difference. Conclusion Compared withα1b interferon interferon alone, α1b interferon combined with gamma globulin was safe and effective in treatment of EB virus infection in children, which could shorten the clinical symptoms improvement time, improve the rate of negative conversion and immune function of children.

R969

廣東省中醫(yī)藥局項目（20171264）