目的 探討文拉法辛聯(lián)合艾司西酞普蘭治療老年焦慮癥的臨床療效及安全性。方法 選取2015年5月-2018年5月青海省第三人民醫(yī)院收治的120例老年焦慮癥患者，根據(jù)其入院順序隨機(jī)分為兩組，每組各60例，對(duì)照組患者給予艾司西酞普蘭治療，初始劑量5 mg/d，后根據(jù)患者病情進(jìn)行調(diào)整，劑量控制在10~20 mg/d，每日1次；觀察組患者給予文拉法辛聯(lián)合艾司西酞普蘭治療，初始劑量75 mg/d，后根據(jù)患者病情進(jìn)行調(diào)整，最高用量控制在200 mg/d，每日1次。連續(xù)治療1個(gè)月。比較兩組的治療效果、漢密爾頓焦慮量表（HAMA）評(píng)分及不良反應(yīng)發(fā)生率。結(jié)果 觀察組治療總有效率為95.00%，顯著高于對(duì)照組的81.67%（P<0.05）。治療后兩組HAMA評(píng)分均顯著低于治療前（P<0.05），且觀察組顯著低于對(duì)照組（P<0.05）。兩組治療期間口干、惡心嘔吐、便秘、頭暈等不良反應(yīng)發(fā)生率無顯著差異。結(jié)論 文拉法辛聯(lián)合艾司西酞普蘭治療老年焦慮癥的療效顯著，可有效緩解患者焦慮癥狀，且安全性較好。

Objective To investigate the clinical efficacy and safety of escitalopram combined with venlafaxine in the treatment of senile anxiety. Methods 120 cases of elderly anxiety patients admitted to our hospital from May 2015 to May 2018 were selected as subjects, according to the order of patients admitted to the hospital, they were randomly divided into study group and control group, 60 cases in each group. Patients in the control group were treated with escitalopram, and patients in the study group were given escitalopram combined with venlafaxine. Then the treatment effect, HAMA score and incidence of adverse reactions were compared between the two groups. Results The total effective rate of the study group was significantly higher than that of the control group (P<0.05). After treatment, the HAMA scores of the two groups were significantly lower than before treatment (P<0.05), and the study group was significantly lower than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions such as dry mouth, dizziness, nausea and vomiting, constipation during the two groups. Conclusion Escitalopram combined with venlafaxine has a significant effect in the treatment of senile anxiety, which can effectively alleviate anxiety symptoms and is safer.

R969.4