目的 探究甘草酸二胺對腹膜透析患者的腹膜功能和炎癥因子的影響。方法 將2017年1月—2018年2月在珠海市人民醫(yī)院接受腹膜透析治療的114例患者隨機(jī)分成對照組和觀察組，每組各57例。對照組采用持續(xù)非臥床腹膜透析（PD），選用1.5% PD液，2 000 mL/次，3～4次/d。觀察組在對照組治療的基礎(chǔ)上口服甘草酸二銨膠囊，150 mg/次，3次/d。兩組干預(yù)時間均為6個月。比較兩組患者治療前后腹膜功能以及血炎癥因子水平的變化。結(jié)果 觀察組的超濾量和肌酐和葡萄糖的比值（D/P）和高于對照組，觀察組的0 h和4 h肌酐比值（D₀/D₄）低于對照組，差異均有顯著性（P<0.05）。治療后，兩組血漿與PD液中結(jié)締組織生長因子（CTGF）、轉(zhuǎn)化生長因子（TGF-β1）和血管內(nèi)皮生長因子（VEGF）水平較治療前均顯著升高（P<0.05）；治療后觀察組的血漿和腹膜透析液TGF-β1、VEGF、CTGF均低于對照組，差異均有顯著性（P<0.05）。觀察組治療后白介素-1（IL-1）、白介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）均顯著低于治療前（P<0.05）；對照組治療后IL-6和TNF-α顯著低于治療前（P<0.05）；治療后觀察組的IL-1和TNF-α顯著低于對照組（P<0.05）。兩組治療后尿素氮（BUN）、肌酐（Cr）水平與治療前相比較均顯著下降（P<0.05）；且治療后觀察組的BUN、Cr水平顯著低于對照組（P<0.05）；兩組患者治療前后K+濃度無明顯變化。結(jié)論 甘草酸二胺能夠明顯改善患者腹膜功能，延緩腹膜纖維化，降低炎癥因子的表達(dá)水平。

Objective To explore the effect of diammonium glycyrrhizinate on peritoneal function and inflammatory factors in peritoneal dialysis patients. Methods Patients (114 cases) who received peritoneal dialysis in Zhuhai People's Hospital from January 2017 to February 2018 were randomly divided into control group and observation group, and each group had 57 cases. Patients in the control group was treated with continuous ambulatory peritoneal dialysis with 1.5% PD solution, 2 000 mL/time, three or four times daily. Patients in the observation group were po administered with Diammonium Glycyrrhizinate Capsules on the basis of control group, 150 mg/time, three times daily. Patients in two groups were treated for 6 months. The changes of peritoneal function and serum inflammatory factors in two groups before and after treatment were compared. Results Ultrafiltration and D/P in the observation group were higher than those in the control group, while D₀/D₄ in the observation were lower than those in the control group (P<0.05). After treatment, the levels of CTGF, TGF-β1 and VEGF in plasma and PD fluid in two groups were significantly higher than those before treatment (P<0.05). After treatment, the levels of TGF-β1, VEGF and CTGF in plasma and PD fluid in observation group were significantly lower than those of the control group (P<0.05). The levels of IL-1, IL-6, TNF-α in the observation group were significantly lower than those before treatment (P<0.05), the levels of IL-6 and TNF-α in the control group were significantly lower than those before treatment (P<0.05), and the levels of IL-1 and TNF-α in the observation group were significantly lower than those in the control group (P<0.05). After treatment, BUN and Cr levels in two groups were significantly lower than those before treatment (P<0.05), and BUN and Cr levels in the observation group were significantly lower than those in the control group (P<0.05). There was no significant change in K⁺ concentration in two groups before and after treatment.Conclusion Diammonium glycyrrhizinate can significantly improve the peritoneal function, delay peritoneal fibrosis, and reduce the expression of inflammatory factors.