目的 研究槐杞黃顆粒聯(lián)合注射用頭孢他啶對肺炎支原體肺炎患兒炎性因子及免疫功能的影響。方法 選擇2015年6月—2017年6月資陽市人民醫(yī)院兒科門診的81例肺炎支原體肺炎患兒為研究對象，將患兒隨機(jī)分為對照組（41例）和觀察組（40例）。對照組靜脈滴注注射用頭孢他啶，10 mg/kg加入到5%葡萄糖注射液100 mL，2次/d；觀察組在對照組治療的基礎(chǔ)上口服槐杞黃顆粒，10 g/次，2次/d。兩組均治療3個月。觀察兩組患兒的臨床療效，比較兩組患兒住院時間、臨床癥狀消退時間、炎癥因子和免疫功能。結(jié)果 觀察組治療的總有效率高于對照組（95.00% vs 73.17%， P<0.05）。治療后，觀察組患兒的肺部濕啰音消退時間、發(fā)熱消退時間、住院時間和咳嗽喘息消失時間均明顯短于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組的血清C反應(yīng)蛋白（CRP）、白細(xì)胞介素（IL）-4以及IL-6水平均明顯降低，IL-10水平均明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；治療后，觀察組炎癥因子水平明顯優(yōu)于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組的CD4⁺/CD8⁺和CD4⁺均明顯升高，CD8⁺明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；治療后，觀察組免疫功能指標(biāo)明顯優(yōu)于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 槐杞黃顆粒聯(lián)合注射用頭孢他啶對肺炎支原體肺炎患兒的治療效果優(yōu)于單純使用頭孢他啶鈉，可以降低炎性因子水平，提升機(jī)體免疫功能。

Objective To investigate the clinical effect of Huaiqihuang Granules combined with Ceftazidime for Injection on inflammatory factors and immune function in children with mycoplasma pneumoniae pneumonia. Methods Patients (81 cases) with mycoplasma pneumoniae pneumonia in Ziyang City People's Hospital from June 2015 to June 2017 were randomly divided into control (41 cases) and observation (40 cases) groups. The control group were iv administered with Ceftazidime for Injection, 10 mg/kg added into 5% glucose injection 100 mL, twice daily. The observation group were po administered with Huaiqihuang Granules on the basis of control group, 10 g/time, twice daily. Children in two groups were treated for 3 months. After treatment, the clinical efficacies were observed, and the hospitalization time, clinical symptom subsided time, inflammatory factors, and immune functions in two groups were compared. Results After treatment, the effective rate of the observation group was 95.00%, which was significantly higher than 73.17% of the control group, and there was difference between two groups (P<0.05). After treatment, the pulmonary rales subsided time, fever subsided time, hospitalization time and cough and wheezing disappeared time in the observation groups were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the serum CRP, IL-4 and IL-6 in two groups were significantly decreased, but the IL-10 level were increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the inflammatory factors level in the observation group was significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, CD4⁺/CD8⁺ and CD4⁺ in two groups were significantly increased, CD8⁺ were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the immune function indexes in the observation group was significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion The efficacy of Huaiqihuang Granules combined with Ceftazidime for Injection on children with mycoplasma pneumoniae pneumonia is better than that of ceftazidime alone, which can reduce the level of inflammatory factors, and enhance the immune function of children.