對于吸入粉霧劑來說，由于活性藥物成分（API）較小的粒徑和較高的表面能，導(dǎo)致微粉易于團(tuán)聚，難以分散。微粒間的內(nèi)聚力和微粒與乳糖間的粘附力導(dǎo)致粉霧劑產(chǎn)品較低的微細(xì)粒子比例（FPF）。通過工程顆?？梢愿纳艫PI微粒的物化性質(zhì)，進(jìn)而顯著提高DPI產(chǎn)品的遞送效率。概述通過工程顆粒的制備API微粉的方法，包括反溶劑結(jié)晶、濕法粉碎/研磨、噴霧/冷凍干燥、超臨界流體等方法，可以顯著提高粉霧劑的霧化性能。

Asa result of small particles size and high surface energy,Active Pharmaceutical Ingredients of DPIs tend to be highly agglomerated and poor dispersible. The DPIs exhibit low FPF due to the cohesion between fine particles and adhesion between fine particles and lactose. Through engineering particles, the physical and chemical properties of API particles can be improved, and the delivery efficiency of DPI products can be significantly improved.Methods of engineering particles were reviewed in the paper,involved antisolvent crystallized,wetmillingnanotechnology,spray/spray-freeze drying.The semethods can significantly improveatomization performance off ogging agent.

國家科技部重大專項(xiàng)（2017ZX09201002）