目的 考察新型細(xì)菌群體抑制劑RNAIII抑制肽衍生物RIP1183對中樞神經(jīng)系統(tǒng)、心血管系統(tǒng)和呼吸系統(tǒng)的影響。方法 將ICR種小鼠48只，隨機分為對照組和RIP1183低、中、高劑量組（4、12、36 mg/kg），觀察iv RIP1183后，對小鼠自主活動次數(shù)、協(xié)調(diào)運動能力和閾下巴比妥鈉協(xié)同作用的影響。將比格犬隨機分組同前，按體表面積換算成相應(yīng)劑量，觀察股iv RIP1183后，對各組犬心血管系統(tǒng)和呼吸系統(tǒng)的影響。結(jié)果 與對照組相比，RIP1183對小鼠自主活動、協(xié)調(diào)運動能力和閾下巴比妥鈉協(xié)同作用無影響，對比格犬心電圖、心率、心律及呼吸頻率和幅度、血壓無明顯影響。結(jié)論 RIP1183對中樞神經(jīng)系統(tǒng)、呼吸系統(tǒng)和心血管系統(tǒng)均無明顯影響。研究結(jié)果可為RIP1183臨床試驗研究提供參考。

Objective To investigate the effects of RIP1183, a novel bacterial population inhibitor RNA III inhibitory peptide derivative, on the central nervous system, cardiovascular system and respiratory system. Methods A total of 48 ICR mice were randomly divided into control group, RIP high, medium, and low dose groups (4, 12 and 36 mg/kg). The effects of iv RIP1183 on the number of spontaneous activities, balance ability, and the synergistic effect of subthreshold sodium barbiturate in mice were observed. The Beagle dogs were randomly divided into the same group and converted into corresponding doses according to body surface area. The effects of iv RIP1183 on cardiovascular and respiratory system were observed. Results Compared with control group, RIP1183 had no effect on mice's autonomic activity, coordinated motor ability, and subthreshold barbiturate synergistic effect. And had no significant effect on ECG, heart rate, rhythm, respiratory rate and amplitude, and the blood pressure of Beagle dogs. Conclusion URIP1183 had no significant effect on the central nervous system, respiratory system and cardiovascular system. The results of the studies can provide references and important guiding significances for the clinical trial of RIP1183.

陜西省科技廳自然科學(xué)基礎(chǔ)研究計劃項目（2018JQ8028）；陜西省呼吸病預(yù)防與診治工程研究中心開放基金（2017HXKF06）；西安醫(yī)學(xué)院博士科研啟動基金（2016DOC27）；國家科技重大專項-重大新藥創(chuàng)制項目（2013ZX09J13108-01B）