目的 研究注射用磷酸肌酸鈉聯(lián)合果糖二磷酸鈉注射液對新生兒窒息患兒心功能的影響。方法 選擇2015年1月—2018年6月寶雞市人民醫(yī)院收治的70例新生兒窒息后心肌損傷患兒作為研究對象，采用抽簽法將患兒隨機分為兩組。對照組將果糖二磷酸鈉注射液250 mg/（kg·d）溶于30 mL的10%葡萄糖溶液中靜脈滴注。觀察組在對照組治療的基礎(chǔ)上，將注射用磷酸肌酸鈉0.5 g溶于30 mL的10%葡萄糖溶液中靜脈滴注。兩組均治療2周。觀察兩組患者的臨床療效，同時比較兩組治療前后的肌酸激酶同工酶（CK-MB）、肌鈣蛋白T（CTnT）、肌酸激酶（CK）和乳酸脫氫酶（LDH）水平及左室射血分?jǐn)?shù)（LVEF）。結(jié)果 治療后，觀察組的總有效率為94.29%，明顯高于對照組的71.43%（P<0.05）。治療后，兩組CKMB、CTnT、CK和LDH水平均明顯降低（P<0.05）；且觀察組血清學(xué)指標(biāo)顯著低于對照組（P<0.05）。治療后，兩組LVEF均明顯升高（P<0.05），且觀察組顯著高于對照組（P<0.05）。結(jié)論 注射用磷酸肌酸鈉聯(lián)合果糖二磷酸鈉注射液可以提高新生兒窒息后心肌損傷的療效，有效改善心功能，具有臨床推廣應(yīng)用價值。

Objective To study the effect of Creatine Phosphate Sodium for Injection combined with Fructose Sodium Diphosphate Injection on cardiac function after neonatal asphyxia. Methods Selected 70 cases of patients with myocardial injury after neonatal asphyxia who were treated in Baoji People's Hospital from January 2015 to June 2018, divided into two groups randomly. Children in the control group were injected with Fructose Sodium Diphosphate Injection, 250 mg/(kg·d) added into 10% glucose solution 30 mL. Children in the observation group were given intravenous infusion of Creatine Phosphate Sodium for Injection on the basis of control group, 0.5 g added into 10% glucose solution 30 mL. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the levels of CK-MB, CTnT, CK, LDH and LVEF in two groups before and after treatment were compared. Results After treatment, the effective rate of the observation group was 94.29%, which was significantly higher than 71.43% in the control group (P<0.05). After treatment, the serum CK-MB, CTnT, CK and LDH levels in two groups were significantly decreased (P<0.05), and the serum indexes in the observation group were significantly lower than those in the control group (P<0.05). After treatment, LVEF were increased significantly in two groups (P<0.05), and the LVEF in the observation group were significantly higher than those in the control group (P<0.05). Conclusion Creatine Phosphate Sodium for Injection combined with Fructose Sodium Diphosphate Injection can improve the efficacy of myocardial injury after neonatal asphyxia, effectively improve cardiac function, with clinical application value.

陜西省教育廳服務(wù)地方專項項目（18JC001）