目的 探討氟哌噻噸美利曲辛片聯(lián)合西沙必利片對胃腸功能紊亂患者負(fù)性情緒及血生化指標(biāo)的影響。方法 選取2016年1月—2017年11月連云港市第一人民醫(yī)院70例胃腸功能紊亂患者作為研究對象，根據(jù)隨機(jī)抽簽原則將受試者分為對照組和觀察組，每組各35例。對照組口服西沙必利片治療，5 mg/次，3次/d；觀察組在對照組的基礎(chǔ)上聯(lián)合氟哌噻噸美利曲辛片治療，1片/次，2次/d。兩組均連續(xù)治療1個月。比較兩組的臨床療效、治療前后各負(fù)面情緒評分及各血生化指標(biāo)水平變化以及不良反應(yīng)發(fā)生情況。結(jié)果 治療后，觀察組的總有效率顯著高于對照組（P<0.05）。治療后，兩組的焦慮、抑郁評分較治療前均明顯下降（P<0.05），且觀察組顯著低于對照組（P<0.05）。治療前后兩組的尿素氮（BUN）、血清中肌酐（Cr）、丙氨酸氨基轉(zhuǎn)移酶（ALT）及肌酸激酶（CK）等血生化指標(biāo)水平比較無統(tǒng)計(jì)學(xué)差異，治療期間兩組均未發(fā)生明顯的不良反應(yīng)。結(jié)論 西沙必片利聯(lián)合氟哌噻噸美利曲辛片可有效改善患者的臨床癥狀及負(fù)性情緒，且不影響血生化指標(biāo)水平，療效安全顯著，在胃腸功能紊亂患者治療中具有積極意義。

Objective To explore effect of Cisapride Tablets combined with Flupentixol and Melitracen Tablets on negative emotion and blood biochemical parameters in patients with gastrointestinal disorders. Methods A total of 70 patients with gastrointestinal disorders were selected as the subjects from January 2016 to November 2017. According to the principle of random lottery, all patients were divided into control group and study group with 35 cases in each group. The control group were treated with Cisapride Tablets, 5 mg/time, three times daily. The observation group were treated with Flupentixol and Melitracen Tablets on the basis of control group, 1 tablet/time, twice daily. Patients in two groups were treated continuously for 1 month. Clinical efficacy, negative emotion scores, changes in blood biochemical indicators, and the incidence of adverse reactions before and after treatment were compared between two groups. Results After treatment, the total effective rate in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the anxiety and depression scores of the two groups were significantly lower than before treatment (P<0.05), and the observation group was significantly lower than the control group (P<0.05). There were no significant differences in blood biochemical indicators of the BUN, Cr, ALT and CK between two groups before and after treatment. No obvious adverse reactions occurred in two groups during the treatment. Conclusion Cisapride Tablets combined with Flupentixol and Melitracen Tablets can effectively improve clinical symptoms and negative emotions, and do not affect the level of blood biochemical indicators, the efficacy is safe and significant, which has positive significance in the treatment of patients with gastrointestinal disorders.

江蘇省衛(wèi)生計(jì)生委課題（BJ16009）