目的 探討喜炎平注射液與鹽酸小檗堿片聯(lián)用對(duì)小兒輪狀病毒腸炎的療效以及對(duì)外周血中性粒細(xì)胞功能的影響。方法 選取2015年8月—2018年9月安康市中醫(yī)醫(yī)院收治的輪狀病毒性腸炎患兒99例，根據(jù)患兒入院先后順序分為兩組。對(duì)照組50例，在常規(guī)治療的基礎(chǔ)上加用鹽酸小檗堿片保留灌腸治療；觀察組49例，在對(duì)照組的基礎(chǔ)上給予喜炎平注射液治療。比較兩組患兒的臨床治療效果、臨床癥狀緩解時(shí)間、輪狀病毒轉(zhuǎn)陰時(shí)間和中性粒細(xì)胞功能。結(jié)果 治療后，觀察組臨床總有效率為91.84%，顯著高于對(duì)照組的76.00%（P<0.05）。治療后，觀察組患者發(fā)熱、嘔吐、腹瀉、腹脹腹痛緩解時(shí)間和輪狀病毒轉(zhuǎn)陰時(shí)間均顯著低于對(duì)照組（P<0.05）。治療后，觀察組的細(xì)胞活化率和刺激指數(shù)顯著高于對(duì)照組（P<0.05）。結(jié)論 喜炎平注射液與鹽酸小檗堿片聯(lián)用可顯著提高輪狀病毒腸炎患兒臨床治療效果，快速緩解臨床癥狀，縮短輪狀病毒轉(zhuǎn)陰時(shí)間，并可提高中性粒細(xì)胞功能，值得臨床借鑒。

Objective To investigate the effect of Xiyanping Injection combined with Berberine Hydrochloride Tablets on rotavirus enteritis and peripheral blood neutrophil function. Methods A total of 99 children with rotavirus enteritis admitted to Ankang Traditional Chinese Medicine Hospital from August 2015 to September 2018 were enrolled. According to the order of admission, the patients were divided into two groups. In the control group, 50 patients were treated with Berberine Hydrochloride Tablets retention enema on the basis of routine treatment. 49 patients in the observation group were treated with Xiyanping Injection on the basis of the control group. The clinical treatment effects in two groups were compared. Clinical symptom relief time, rotavirus negative time, and neutrophil function were compared. Results After treatment, the total clinical effective rate of the observation group was 91.84%, which was significantly higher than 76.00% of the control group (P<0.05). After treatment, the time of fever, vomiting, diarrhea, abdominal distension and abdominal decay, and rotavirus negative time in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the cell activation rate and stimulation index in the observation group were significantly higher than those in the control group (P<0.05). Conclusion Xiyanping Injection combined with Berberine Hydrochloride Tablets can significantly improve the clinical treatment effect of children with rotavirus enteritis, rapidly relieve clinical symptoms, shorten rotavirus conversion time, and improve neutrophil function, which is worthy of clinical reference.

陜西省衛(wèi)生廳科研基金項(xiàng)目（2015JM40236）