目的 探究嗎替麥考酚酯分散片聯(lián)合醋酸潑尼松片治療兒童腎病綜合征的效果。方法 選擇2016年1月—2018年1月于常州市兒童醫(yī)院接受治療的50例腎病綜合征患兒作為研究對(duì)象，采用奇偶數(shù)法將患兒均分為兩組，每組各25例。對(duì)照組接受環(huán)孢素軟膠囊聯(lián)合醋酸潑尼松片治療，實(shí)驗(yàn)組接受替麥考酚酯分散片聯(lián)合醋酸潑尼松片治療，兩組均持續(xù)治療6個(gè)月。對(duì)比兩組臨床治療總有效率、治療中不良反應(yīng)發(fā)生率及治療前后IgA、IgG、IgM、蛋白排泄率（UAER）、血漿白蛋白（Alb）、尿素氮（BUN）、血肌酐（Scr）等指標(biāo)變化。結(jié)果 治療后，實(shí)驗(yàn)組治療總有效率顯著高于對(duì)照組（P<0.05）。治療后，兩組IgA、IgG、IgM水平均高于治療前，且實(shí)驗(yàn)組高于對(duì)照組（P<0.05），但對(duì)照組治療后IgM水平與治療前差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。治療后，兩組UAER、BUN及Scr水平均顯著降低，而Alb顯著升高，且實(shí)驗(yàn)組改善更顯著（P<0.05）。兩組治療期間藥物不良反應(yīng)發(fā)生率無(wú)顯著差異（P>0.05）。結(jié)論 嗎替麥考酚酯分散片聯(lián)合醋酸潑尼松片治療兒童腎病綜合征的效果良好，能夠顯著改善患兒免疫功能和腎功能，提高臨床療效，且治療安全性較高。

Objective To investigate the effect of Mycophenolate Mofetil Tablets combined with Prednisone Acetate Tablets in treatment of children with nephrotic syndrome. Methods Children (50 cases) with nephrotic syndrome in Changzhou Children's Hospital from January 2016 to January 2018 were divided into two groups according to odd and even number method, and each group had 25 cases. The control group were treated for Ciclosporin Soft Capsules combined with Prednisone Acetate Tablets. The experimental group were treated for Mycophenolate Mofetil Tablets combined with Prednisone Acetate Tablets. The two groups continued treatment for 6 months. Comparing the total effective rate of clinical treatment, the incidence of adverse reactions in the treatment, and IgA, IgG, IgM, UAER, Alb, BUN, Scr levels in two groups before and after treatment. Results The total effective rate of the experimental group was significantly higher than that of the control group (P<0.05). After treatment, the levels of IgA, IgG and IgM in two groups were higher than those before treatment, and the experimental group was higher than the control group (P<0.05). However, there was no significant difference in the level of IgM between two groups after treatment (P>0.05). After treatment, the levels of UAER, BUN and Scr were significantly decreased in two groups, while the levels of Alb were significantly increased, and the improvement in the experimental group was more significant (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P>0.05).Conclusion Mycophenolate Mofetil Tablets combined with Prednisone Acetate Tablets is effective in treatment of children with nephrotic syndrome, which can significantly improve the immune function and renal function of children, improve the clinical efficacy, and has higher treatment safety.

江蘇省科技專項(xiàng)項(xiàng)目（BL2014037）