目的 探討重組人腦利鈉肽凍干粉劑聯(lián)合豬肺磷脂注射液治療窒息兒早產(chǎn)兒對(duì)右室Tei指數(shù)的影響。方法 采用回顧性、便利抽樣研究方法，選取2015年8月—2018年1月在鄭州市第七人民醫(yī)院診治的窒息兒早產(chǎn)兒120例作為研究對(duì)象，根據(jù)治療方法的不同分為觀察組60例與對(duì)照組60例。對(duì)照組給予豬肺磷脂注射液200 mg/kg氣管滴注結(jié)合呼吸支持治療，觀察組在對(duì)照組治療的基礎(chǔ)上給予重組人腦利鈉肽凍干粉劑輔助治療，負(fù)荷劑量0.5 μg/kg，維持劑量速率為0.005～0.01μg/（kg·min），治療48 h。記錄兩組患兒機(jī)械通氣時(shí)間、住院天數(shù)、BNP水平、左室與右室Tei指數(shù)變化情況及患兒治療后2、24 h的肺泡內(nèi)正壓參數(shù)。結(jié)果 觀察組的機(jī)械通氣時(shí)間與住院天數(shù)分別為（2.74±0.87）d和（22.19±3.29）d，都顯著短于對(duì)照組的（5.29±1.20）d和（27.82±3.11）d（P<0.05）。治療后，兩組的BNP值都顯著低于治療前（P<0.05），治療后觀察組的BNP值與對(duì)照組相比無顯著差異。兩組治療后的左室與右室的Tei指數(shù)都顯著高于治療前（P<0.05），治療后觀察組的Tei指數(shù)也顯著高于對(duì)照組（P<0.05）。觀察組治療后2、24 h的肺泡內(nèi)正壓參數(shù)都顯著高于對(duì)照組（P<0.05）。結(jié)論 重組人腦利鈉肽凍干粉劑聯(lián)合豬肺磷脂注射液治療窒息兒早產(chǎn)兒能改善患兒的右室Tei指數(shù)，調(diào)節(jié)體內(nèi)BNP水平，改善肺泡內(nèi)正壓參數(shù)，從而促進(jìn)患兒康復(fù)。

Objective To investigate the effects of recombinant human brain natriuretic peptide freeze-dried powder combined with Poractant Alfa Injection on right ventricular Tei index in asphyxiated premature infants. Methods Used a retrospective, convenience sampling method, 120 cases of asphyxiated premature infants in Zhengzhou NO.7 People's Hospital from August 2015 to January 2018 were selected as the research object, children were divided into the observation (60 cases) and control (60 cases) groups according to the different treatment methods. Children in the control group were received 200 mg/kg intratracheal infusion of Poractant Alfa Injection combined with respiratory support treatment. Children in the observation group was given recombinant human brain natriuretic peptide freeze-dried powde adjuvant therapy based on the control group, the load dose was 0.5μg/kg, the maintenance dose rate was 0.005-0.01μg/(kg·min), and the treatment lasted 48 h. Mechanical ventilation time, hospitalization days, BNP level, changes of left and right ventricular Tei index, and alveolar positive pressure parameters at 2 and 24 h after treatment were recorded. Results After treatment, the duration of mechanical ventilation and hospitalization days in the observation group were (2.74 ±0.87) d and (22.19 ±3.29) d, respectively, which were significantly less than those in the control group of (5.29 ±1.20) d and (27.82 ±3.11) d (P<0.05). After treatment, the BNP value in two groups were significantly lower than that of the control group (P<0.05), and the BNP value in the observation group was not significantly different compared to the control group after treatment. After treatment, Tei index of left ventricle and right ventricle in two groups were significantly higher than that before treatment (P<0.05), and the Tei index in the observation group were also higher than that of the control group (P<0.05). The positive pressure in the alveolar of 2 and 24 h after treatment in the observation group were significantly higher than that in the control group (P<0.05). Conclusion The recombinant human brain natriuretic peptide freeze-dried powder combined with Poractant Alfa Injection can improve the right ventricular Tei index, and regulate the level of BNP in vivo, and improve the positive parameters of alveolar pressure in asphyxiated premature infants, so as to promote the rehabilitation of children.