中藥引起的不良反應(yīng)中類過敏反應(yīng)發(fā)生率逐年增高，對人類健康造成了嚴(yán)重的威脅。由于國內(nèi)外對類過敏反應(yīng)發(fā)生的機(jī)制尚不完全清楚，評價方法尚不成熟，導(dǎo)致藥物類過敏反應(yīng)的預(yù)測與評價存在不同程度的局限性。為了更好地了解類過敏反應(yīng)，解決中藥致敏成分的研究與中藥注射劑的安全性評價問題，總結(jié)歸納了目前有關(guān)藥物誘導(dǎo)的類過敏反應(yīng)發(fā)生機(jī)制及臨床前評價模型等內(nèi)容，通過對比分析，為后期深入研究提供依據(jù)和方法學(xué)指導(dǎo)。

The incidence of pseudo-allergy is the highest among the adverse drug reactions induced by Traditional Chinese Medicine (TCM), which threatens the public health seriously. The lack of research on mechanisms and evaluation models of pseudo-allergy results in different degrees of limitation on prediction and assessment on safety of drugs. In order to better understand the kind of allergic reaction, solve the allergic components and improve the safety of TCM, we summarize the mechanisms and evaluation models in vitro and in vivo of drug-induced pseudo-allergy for further study.

軍隊(duì)醫(yī)療機(jī)構(gòu)制劑標(biāo)準(zhǔn)提高科研專項(xiàng)（14ZJZ08）