冠心病是威脅人類健康的主要疾病之一，其患病率及死亡率逐年上升。依折麥布作為一種膽固醇腸吸收抑制劑，通過改善血脂水平、抑制炎癥反應、縮小或逆轉(zhuǎn)斑塊，發(fā)揮抗動脈粥樣硬化作用，延緩冠心病的發(fā)生和進展，并抑制炎性反應，改善血管內(nèi)皮功能，從而減少臨床終點事件的發(fā)生，提升患者療效及預后水平。對依折麥布治療冠心病的作用機制及臨床療效的研究進展進行綜述。

Coronary heart disease is one of the major diseases that threaten human health, and its prevalence and mortality increase year by year. Coronary heart disease is the most common type of organ lesion caused by atherosclerosis. As a cholesterol intestinal absorption inhibitor, by improving blood lipid levels, inhibiting inflammatory reactions, reducing or reversing plaque, play an antiatherosclerotic effect, thus delaying the occurrence and development of coronary heart disease, and inhibit inflammatory reactions, improve vascular endothelial function, thereby reducing the occurrence of clinical endpoints, improve the efficacy and prognosis of patients. A review of the research progress on the mechanism of action and clinical therapeutic effect of ezetimibe in the treatment of coronary heart disease.