目的 探討百蕊顆粒聯(lián)合頭孢克洛顆粒治療小兒急性支氣管炎的臨床療效。方法 選取2017年5月—2019年5月在海南醫(yī)學(xué)院第一附屬醫(yī)院進(jìn)行治療的86例急性支氣管炎患兒為研究對象，根據(jù)用藥的差別將患兒分為觀察組（43例）和對照組（43例）。對照組給予頭孢克洛顆粒，20～40 mg/（kg·d），分3次給予，1日總量不超過1 g；觀察組在對照組基礎(chǔ)上口服百蕊顆粒，5 g/次，3次/d。兩組患兒均經(jīng)7 d治療后進(jìn)行效果對比。結(jié)果 經(jīng)治療，對照組總有效率為81.40%，顯著低于觀察組的97.67%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，觀察組咳嗽咳痰、喘息氣急、發(fā)熱及肺部啰音消失時(shí)間均短于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。經(jīng)治療，兩組血清超敏C反應(yīng)蛋白（hs-CRP）、降鈣素原（PCT）、腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-6（IL-6）、可溶性髓系細(xì)胞觸發(fā)受體-1（sTREM-1）水平均顯著下降，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組血清學(xué)指標(biāo)顯著低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 百蕊顆粒聯(lián)合頭孢克洛顆粒治療小兒急性支氣管炎可顯著促進(jìn)患兒癥狀改善，降低炎癥細(xì)胞因子水平，具有良好的臨床應(yīng)用價(jià)值。

Objective To explore the clinical effect of Bairui Granules combined with Cefaclor Granules in treatment of acute bronchitis in children. Methods Children (86 cases) with acute bronchitis treated in The First Affiliated Hospital of Hainan Medical University from May 2017 to May 2019 were divided into observation group (43 cases) and control group (43 cases) according to the difference of medication. The control group was given Cefaclor Granules, 20 — 40 mg/(kg· d) for three times, and the total amount of Cefaclor Granules per day was no more than 1 g. Children in the observation group were po administered Bairui Granules on the basis of the control group, 5 g/time, three times daily. The effect of 7 d treatment was compared between the two groups. The therapeutic effect in two groups was compared after treatment for 7 d. Results After treatment, the effective rate in the control group was 81.40%, which was significantly lower than 97.67% in the observation group, and there were differences between two groups (P < 0.05). After treatment, the disappearance time of symptoms such as cough and sputum, shortness of breath, fever, and lung rale in the observation group were significantly better than those in the control group, and there were differences between two groups (P < 0.05). After treatment, the serum levels of hs-CRP, PCT, TNF- α, IL-6, and sTREM-1 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, serological indexes in the observation group was significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Bairui Granules combined with Cefaclor Granules in treatment of children with acute bronchitis can effectively improve the clinical symptoms, and reduce the inflammatory cytokines levels, which has good clinical application value.

R974

海南省衛(wèi)生計(jì)生行業(yè)科研項(xiàng)目（16A200012）