目的 探討胃炎寧顆粒聯(lián)合膠體果膠鉍膠囊治療慢性萎縮性胃炎的臨床療效。方法 選取2017年4月—2018年4月在儋州市人民醫(yī)院進(jìn)行治療110例慢性萎縮性胃炎患者作為研究對象，根據(jù)入院的順序?qū)⒒颊叻譃橛^察組（55例）和對照組（55例）。對照組給予膠體果膠鉍膠囊，2粒/次，4次/d；觀察組在對照組的基礎(chǔ)上口服胃炎寧顆粒，15 g/次，3次/d。兩組均治療4周。觀察兩組患者的臨床療效，同時(shí)比較兩組治療前后的癥候積分、SF-36量表評分、血清炎性因子水平和血清學(xué)指標(biāo)。結(jié)果 經(jīng)治療，對照組有效率為85.45%，顯著低于觀察組的98.18%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組相關(guān)臨床癥候積分均顯著降低（P<0.05），且以觀察組最為明顯（P<0.05）。治療后，兩組SF-36量表評分均顯著提高（P<0.05），且以觀察組最明顯（P<0.05）。治療后，兩組在血清超敏C反應(yīng)蛋白（hs-CRP）、白細(xì)胞介素-8（IL-8）、腫瘤壞死因子-α（TNF-α）、可溶性白細(xì)胞介素-2受體（sIL-2R）水平均顯著改善（P<0.05），且觀察組更為明顯（P<0.05）。治療后，兩組血清前列腺素E2（PGE₂）、血管內(nèi)皮生長因子（VEGF）、胃泌素（GAS）、胃泌素-17（G-17）、生長抑素（SS）水平均顯著改善（P<0.05），且觀察組更明顯（P<0.05）。結(jié)論 胃炎寧顆粒聯(lián)合膠體果膠鉍膠囊治療慢性萎縮性胃炎可有效改善患者臨床癥狀，降低機(jī)體炎癥反應(yīng)和改善機(jī)體血清學(xué)指標(biāo)水平，具有良好臨床應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Weiyanning Granules combined with Colloidal Bismuth Pectin Capsules in treatment of chronic atrophic gastritis. Methods Patients (110 cases) with chronic atrophic gastritis were treated in Danzhou People's Hospital from April 2017 to April 2018 were divided into observation group (55 cases) and control group (55 cases) according to the admission sequence. The control group was given Colloidal Bismuth Pectin Capsules, 2 grains/time, four times daily. Patients in the observation group were po administered with Weiyanning Granules on the basis of control group, 15 g/time, three times daily. Patients in two groups were treated for 4 weeks. The clinical efficacy in two groups was observed, and the symptom scores, ST-36 scale scores, serum inflammatory factor levels, and serological indicators before and after treatment were compared. Results After treatment, the effective rate in the control group was 85.45%, which was significantly lower than 98.18% in the obseration group, and there were differences between two groups (P < 0.05). After treatment, the scores of related clinical symptoms in two groups were decreased (P < 0.05), and the observation group was the most obvious (P < 0.05). After treatment, the SF-36 scores in two groups were significantly improved (P < 0.05), and the observation group was the most obvious (P < 0.05). After treatment, the serum levels of hs-CRP, IL-8, TNF-α, and SIL-2R in two groups were significantly improved (P < 0.05), and the observation group was the most obvious (P < 0.05). After treatment, the serum levels of PGE₂, VEGF, GAS, G-17, and SS in two groups were significantly improved (P < 0.05), and the observation group was the most obvious (P < 0.05). Conclusion Weiyanning Granules combined with Colloidal Bismuth Pectin Capsules can effectively improve the clinical symptoms of patients with chronic atrophic gastritis, reduce the inflammation, and improve the levels of serological indicators. It has good clinical application value.

R975

三亞市醫(yī)療衛(wèi)生科技創(chuàng)新項(xiàng)目（2019YW14）