目的 研究甲基多巴片聯(lián)合苯磺酸氨氯地平片對妊娠高血壓疾病的療效。方法 選擇2016年1月—2019年1月西安交通大學(xué)醫(yī)學(xué)部附屬三二〇一醫(yī)院收治的74例妊娠高血壓疾病患者作為研究對象，根據(jù)入院的順序，采用數(shù)字表法將患者隨機(jī)分為兩組。其中對照組清晨空腹服用苯磺酸氨氯地平片，5 mg/次，1次/d。觀察組聯(lián)合口服甲基多巴片，250 mg/次，3次/d。兩組均給藥1周。觀察兩組的臨床療效，比較兩組患者的妊娠結(jié)局，血壓、血肌酐（Cr）、尿素氮（BUN）和24 h尿蛋白水平。結(jié)果 治療后，觀察組治療的總有效率顯著高于對照組（P<0.05）。治療后，觀察組的胎盤早剝率、產(chǎn)后出血率、胎兒窘迫率、剖宮產(chǎn)率、低體質(zhì)量兒率以及新生兒窒息率均明顯低于對照組（P<0.05）。兩組治療后的收縮壓（SBP）、平均動脈壓（MAP）和舒張壓（DBP）均明顯降低（P<0.05），且觀察組顯著低于對照組（P<0.05）。兩組治療后的24 h尿蛋白水平均顯著降低（P<0.05），且觀察組顯著低于對照組（P<0.05），而Cr和BUN水平治療前后兩組均無統(tǒng)計學(xué)差異。結(jié)論 甲基多巴片聯(lián)合苯磺酸氨氯地平片對妊娠高血壓疾病具有較好的療效，能有效控制血壓，改善妊娠結(jié)局和腎功能。

Objective To study the efficacy of Methyldopa Tablets combined with Amlodipine Besylate Tablets on gestational hypertension. Methods Patients (74cases) with gestational hypertension who were admitted to Xi 'an Jiaotong University Affiliated to Medicine 321 Hospital from January 2016 to January 2019 were randomly divided into two groups according to the order of admission. Patients in the control group were po administered with Amlodipine Besylate Tablets in the morning, 5 mg/time, once daily. Patients in the observation group was combined with oral Methyldopa Tablets, 250 mg/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and pregnancy outcome, blood pressure, the levels of Cr, BUN, and 24 h urine protein in two groups were compared. Results After treatment, the total effective rate in the observation group was significantly higher than that of the control group (P < 0.05). After treatment, the placental abruption rate, postpartum hemorrhage rate, fetal distress rate, cesarean section rate, low birth weight rate, and neonatal asphyxia rate in the observation group were significantly lower than those in the control group (P < 0.05). The SBP, MAP and DBP in two groups were significantly decreased after treatment (P < 0.05), and the observation group was significantly lower than those in the control group (P < 0.05). The 24 h urine protein levels were significantly decreased in two groups after treatment (P < 0.05). The observation group was lower than control group (P < 0.05), but Cr and BUN was no significant difference between two groups before and after treatment. Conclusion Methyldopa Tablets combined with Amlodipine Besylate Tablets has a good curative effect on gestational hypertension. It can effectively control blood pressure and improve pregnancy outcome and renal function.

R984

陜西省衛(wèi)計委資助項目（2016D069）