苦參堿能防治二乙基亞硝胺誘發(fā)大鼠原發(fā)性肝癌和小鼠肝癌H22細(xì)胞移植瘤在小鼠體內(nèi)的生長。體外實(shí)驗發(fā)現(xiàn)苦參堿能濃度相關(guān)地抑制肝癌H22細(xì)胞、SMMC-7721細(xì)胞、BEL-7402細(xì)胞、BEL-7404細(xì)胞、Hep3B細(xì)胞、QGY細(xì)胞、QGY/CDDP細(xì)胞、97H細(xì)胞、CRBH-7919細(xì)胞、CRBH-7919/mdr1細(xì)胞增殖、黏附、遷移、侵襲并誘導(dǎo)凋亡，也能誘導(dǎo)人肝癌SMMC-7721細(xì)胞、BEL-7402細(xì)胞、BEL-7404細(xì)胞、化學(xué)品誘發(fā)肝癌大鼠體內(nèi)的低分化肝卵圓細(xì)胞分化，也能提高荷瘤機(jī)體的免疫調(diào)節(jié)功能。臨床上苦參堿注射液正在試用于肝癌的治療和復(fù)發(fā)的預(yù)防。

Matrine has the effects in the prophylaxis and treatment of rat hepatoma induced by diethylnitrosamine, and growth of murine hepatocarcinoma cell H22 transplantation tumor in mice. Matrine inhibits proliferation, adhesion, migration, invasion, and induces apoptosis in association with dosage on hepatoma H22 cells, SMMC-7721 cells, BEL-7702 cells, BEL-7704 cells, Hep3B cells, QGY cells, QGY/CDDP cells, 97H cells, CRBH-7919 cells, CRBH-7919/mdr1 cells in vitro. Matrine induces differentiation in hepatoma SMMC-7721 cells, BEL-7702 cells, BEL-7404 cells, and poorly differentiated hepatic oval cells too. Matrine elevates immunoregulative function in tumor-bearing body too. In clinical application matrine is being tried to treat and prevent recurrence of heptocarcinoma.

R285.6