目的 觀察咳喘順丸聯(lián)合多索茶堿片治療慢性支氣管炎的臨床效果。方法 選擇2016年9月—2018年3月三亞市人民醫(yī)院治療的慢性支氣管炎患者125例，采用隨機(jī)數(shù)法將患者隨機(jī)分為對照組（62例）和觀察組（63例）。對照組采用多索茶堿片進(jìn)行治療，0.2 g/次，2次/d。觀察組在對照組治療的基礎(chǔ)上服用咳喘順丸進(jìn)行治療，5 g/次，3次/d。兩組患者均接受1個月治療。觀察兩組臨床療效，對比患者臨床癥狀消失時間、炎癥介質(zhì)水平以及不良反應(yīng)情況。結(jié)果 治療后，觀察組患者治療總有效率顯著高于對照組（P<0.05）。治療后，觀察組咳痰、喘息、咳嗽3項(xiàng)癥狀消失時間明顯比對照組短（P<0.05）。治療后，兩組腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-6（IL-6）、C反應(yīng)蛋白（CRP）和白細(xì)胞介素-4（IL-4）水平均明顯降低（P<0.05），且治療后，觀察組TNF-α、IL-6、CRP和IL-4水平明顯低于對照組（P<0.05）。兩組不良反應(yīng)發(fā)生率無顯著差異。結(jié)論 咳喘順丸聯(lián)合多索茶堿片治療慢性支氣管炎可明顯改善患者臨床癥狀，緩解炎癥反應(yīng)，該方法具有較好的臨床療效，安全可靠，臨床應(yīng)用價值較高，值得應(yīng)用推廣。

Objective To observe the clinical effect on Kechuanshun Pills combined with Doxofylline Tablets in treatment of chronic bronchitis. Methods A total of 125 patients with chronic bronchitis treated in Sanya People's Hospital from September 2016 to March 2018 were selected. and randomly divided into control group (62 cases) and observation group (63 cases). The control group was treated with Doxofylline Tablets, 0.2 g/time, twice daily. While the observation group was treated with Kechuanshun Pills on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 1 month. The clinical efficacy was observed, and the time of clinical symptoms disappear, the level of inflammatory factor, and adverse reactions in two groups were compared. Results The total effective rate of observation group was significantly higher than that of control group (P<0.05). After treatment, clinical symptoms disappear time of expectoration, wheezing and cough in the observation group was significantly shorter than that in the control group (P<0.05). After treatment, the levels of TNF-α, IL-6, CRP and IL-4 in two groups were significantly decreased (P<0.05), and the levels of TNF-α, IL-6, CRP and IL-4 in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between two groups. Conclusion Kechuanshun Pills combined with Doxofylline Tablets in treatment of chronic bronchitis can significantly improve the clinical symptoms of patients, and relieve inflammatory reaction. This method has good clinical efficacy, safety and reliability, and high clinical application value, which is worthy of application and promotion.

R974

三亞市醫(yī)療衛(wèi)生科技創(chuàng)新項(xiàng)目（2017YW05）