目的 探討丹田降脂丸聯(lián)合依折麥布片治療高脂血癥的臨床效果。方法 選取2017年2月—2019年2月遼寧省人民醫(yī)院收治的92例高脂血癥患者，運用隨機數(shù)字表法將其隨機分成觀察組（n=46）與對照組（n=46）。對照組口服依折麥布片，10 mg/次，1次/d；觀察組在對照組基礎(chǔ)上口服丹田降脂丸，1 g/次，2次/d。兩組均治療8周。對比兩組臨床療效，同時比較兩組患者治療前后的三酰甘油（TG）、總膽固醇（TC）、高密度脂蛋白膽固醇（HDL-C）、低密度脂蛋白膽固醇（LDL-C）、全血高切黏度（HBV）、全血低切黏度（LBV）、紅細胞變形指數(shù)（RDI）、血小板最大聚集率（MAR）值，血漿纖維蛋白原（FIB）、血清C反應(yīng)蛋白（CRP）、血清腫瘤壞死因子-α（TNF-α）及瘦素（LEP）水平。結(jié)果 治療后，觀察組總有效率為95.7%，顯著高于對照組的82.6%（P<0.05）。兩組治療后血清TG、TC、LDL-C水平均顯著低于治療前，而HDL-C水平均顯著升高（P<0.05）；且治療后，觀察組血脂水平的改善效果顯著優(yōu)于對照組（P<0.05）。與治療前相比，兩組治療后HBV、LBV、MAR值均顯著降低，RDI值則顯著增加（P<0.05）；且觀察組血液流變學參數(shù)及MAR值的改善效果更顯著（P<0.05）。兩組治療后血漿FIB水平及血清CRP、TNF-α、LEP水平較治療前均顯著下降（P<0.05）；治療后，觀察組血漿FIB水平及血清CRP、TNF-α、LEP水平較對照組顯著更低（P<0.05）。結(jié)論 應(yīng)用丹田降脂丸聯(lián)合依折麥布片治療高脂血癥的整體療效切實，有助于糾正血脂異常，改善血液高凝狀態(tài)，抑制血小板聚集，防止血栓形成，減輕機體炎性損傷，改善LEP抵抗，且病人耐受性好，值得臨床推廣應(yīng)用。

Objective To investigate the clinical effect of Dantian Jiangzhi Pills combined with Ezetimibe Tablets in treatment of hyperlipidemia. Methods Patients (92 cases) with hyperlipidemia admitted to Liaoning Provincial People's Hospital from February 2017 to February 2019 were randomly divided into observation group (n=46) and control group (n=46) by random number table method. The control group was treated with Ezetimibe Tablets 10 mg/time, once daily. While the observation group was treated with Dantian Jiangzhi Pills on the basis of control group, 1 g/time, twice daily. All patients were treated for 8 weeks. The clinical effects in two groups were compared, and the levels of TG, TC, HDL-C, LDL-C, HBV, LBV, RDI, MAR, FIB, CRP, TNF-α, and LEP in two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 95.7%, which was significantly higher than 82.6% of the control group (P<0.05). After treatment, the serum TG, TC, LDL-C levels in two groups were significantly lower than those before treatment, while HDL-C levels were significantly increased (P<0.05). After treatment, the improvement effect of blood lipid levels in the observation group was significantly better than those in the control group (P<0.05). Compared with before treatment, HBV, LBV, and MAR values in two groups were significantly decreased, but RDI values were significantly increased (P<0.05). In addition, the improvement effect of hemorheology parameters and MAR value in the observation group was more significant (P<0.05). After treatment, the levels of plasma FIB, and serum CRP, TNF-α and LEP in two groups were decreased significantly (P<0.05). After treatment, the plasma FIB level, CRP, TNF-α and LEP levels in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Dantian Jiangzhi Pills combined with Ezetimibe Tablets in treatment of hyperlipidemia has a practical overall effect, which is helpful to correct the abnormal blood lipid, improve the blood hypercoagulable state, inhibit platelet aggregation, prevent thrombosis, reduce the inflammatory damage of the body, improve the LEP resistance, and the patient has a good tolerance, which is worthy of clinical application.

R973