苦參堿能劑量相關(guān)地抑制人肝癌HepG2細(xì)胞增殖、遷移、侵襲和血管內(nèi)皮生長(zhǎng)因子表達(dá)，能誘導(dǎo)HepG2細(xì)胞凋亡和分化?？鄥A是HepG2細(xì)胞的自噬早期誘導(dǎo)劑，更是自噬晚期抑制劑，其通過誘導(dǎo)線粒體應(yīng)繳、內(nèi)質(zhì)網(wǎng)應(yīng)激和抑制ERK信號(hào)通路、人宮頸癌基因-1、Apollon基因表達(dá)和端粒酶活性，產(chǎn)生抗HepG2細(xì)胞的作用。

Matrine inhibits proliferation, migration, invasion, and expression of vascular endothelial growth factor, and induces apoptosis and differentiation in association with dosage on human hepatoma HepG2 cells. Matrine is a inducer of early stage of autophagy, and is more a inhibitor of late stage of autophagy. Matrine has the effect against HepG2 cells by induction of mitochondria stress and endoplasmic reticulum stress, and inhibition of ERK pathway, expression of human cervical cancer oncogene-1 and Apollon gene, and telomerase activity.

R288.1