目的 探討穩(wěn)心顆粒聯(lián)合苦碟子注射液治療勞力型心絞痛的臨床療效。方法 選擇2017年1月-2019年12月在酒泉市中醫(yī)院治療的160例勞力型心絞痛患者作為研究對(duì)象，所有患者按照隨機(jī)數(shù)字表法分為觀察組（n=80）和對(duì)照組（n=80）。對(duì)照組患者靜脈滴注苦碟子注射液，40 mL/次，用0.9%氯化鈉注射液稀釋至250 mL，1次/d。觀察組在對(duì)照組的基礎(chǔ)上口服穩(wěn)心顆粒，1袋/次，3次/d。14 d為1個(gè)療程，兩組均治療1個(gè)療程。治療后，觀察兩組患者的臨床療效和證候療效，同時(shí)比較兩組患者心絞痛發(fā)作情況、治療前后的超氧化物歧化酶（SOD）和丙二醛（MDA）水平。結(jié)果 治療后，觀察組和對(duì)照組總有效率分別為78.75%、60.00%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，觀察組和對(duì)照組證侯療效總有效率分別為81.25%、63.75%，兩組證侯療效總有效率比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，觀察組心絞痛發(fā)作次數(shù)、持續(xù)時(shí)間均顯著少于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清SOD水平較治療前明顯上升，MDA水平明顯下降，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組SOD水平顯著高于對(duì)照組，MDA水平明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 穩(wěn)心顆粒聯(lián)合苦碟子注射液治療勞力型心絞痛，可提高氧化能力，清除氧自由基，減輕相關(guān)中醫(yī)癥侯，療效好，安全性高，值得臨床推廣。

Objective To explore the efficacy of Wenxin Granules combined with Kudiezi Injection in the treatment of exertional angina. Methods Patients (160 cases) with exertional angina from January 2017 to December 2019 in the Jiuquan Traditional Chinese Medicine Hospital were selected. According to the random number table method, patients were divided into the observation group (n=80) and the control group (n=80). Patients in the control group were iv administered with Kudiezi Injection, 40 mL/time, dilute to 250 mL with 0.9% sodium chloride injection, once daily. Patients in the observation group po administered with Wenxin Granules on the basis of control group, 1 bag/time, three times daily. 14 d was a course of treatment, both groups were treated for one course of treatment. After the treatment, the clinical effect and syndrome effect of two groups were observed, and the angina attack, the level of SOD and MDA before and after the treatment were compared. Results After treatment, the total effective rates of the observation group and the control group were 78.75% and 60.00%, respectively, the difference between the two groups was statistically significant (P<0.05). After treatment, the total effective rate of syndrome effect in the observation group and the control group were 81.25% and 63.75%, respectively, the difference between two groups was statistically significant (P<0.05). After treatment, the number and duration of angina attacks in the observation group were significantly less than those in the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the serum SOD level in two groups was increased significantly, but the MDA level was decreased, and the difference before and after treatment in the same group was statistically significant (P<0.05). Moreover, SOD level in the observation group was significantly higher than that in the control group, and MDA level was significantly lower than that in the control group, and the difference between two groups was statistically significant (P<0.05). Conclusion Wenxin Granules combined with Kudiezi Injection in the treatment of exertional angina can improve the oxidation ability, remove oxygen free radicals, and relieve the symptoms of traditional Chinese medicine, with good efficacy and high safety, which was worthy of clinical promotion.

R972

甘肅省中醫(yī)藥管理局科研課題（GZK-2017-66）