目的 探討布拉氏酵母菌聯(lián)合蒙脫石散對(duì)急性腹瀉患兒治療效果及T細(xì)胞亞群的影響。方法 選取2018年8月— 2019年5月在亳州市人民醫(yī)院治療的急性腹瀉患兒64例為研究對(duì)象，根據(jù)就診順序?qū)⒒颊叻譃閷?duì)照組和觀察組，每組各32例。對(duì)照組患兒口服蒙脫石散，1歲以內(nèi)：1.5 g/次，2次/d；1～2歲：3.0 g/次，2次/d；2歲以上3.0 g/次，3次/d，觀察組在服用蒙脫石散后2 h口服布拉氏酵母菌散治療，1歲以內(nèi)：0.125 g/次，2次/d；1歲以上：0.25 g/次，2次/d。兩組均根據(jù)患兒癥狀改善情況治療4～7 d。比較兩組的治療總有效率、癥狀改善情況、治療前后T細(xì)胞亞群指標(biāo)變化及用藥安全性。結(jié)果 治療后，觀察組治療總有效率為93.75%，明顯高于對(duì)照組的75.00%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后3 d，觀察組的大便頻次及大便性狀評(píng)分、止瀉時(shí)間均顯著少于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的CD3⁺、CD4⁺及CD4⁺/CD8⁺均明顯升高（P<0.05），且觀察組T淋巴細(xì)胞亞群水平顯著高于對(duì)照組（P<0.05）。兩組均未出現(xiàn)藥物不良反應(yīng)。結(jié)論 布拉氏酵母菌聯(lián)合蒙脫石散可有效緩解腹瀉癥狀，提高患兒機(jī)體免疫力，療效安全可靠，值得在小兒急性腹瀉治療中推廣應(yīng)用。

Objective To explore effect of Saccharomyces boulardii combined with Montmorillonite Powder on the treatment effect and T cell subsets in children with acute diarrhea. Methods 64 children with acute diarrhea in Bozhou people's hospital from August 2018 to May 2019 were devided into control and observation groupe according to the order of treatment, each group had 32 cases. Children in the control group were po administered with Montmorillonite Powder, children within 1 year old:1.5 g/time, twice daily; 1-2 years old:3.0 g/time, twice daily; over 2 years old:3.0 g/time, three times daily. Children in the observation group were po administered with Saccharomyces boulardii sachets 2 h after taking Montmorillonite Powde, children within 1 year old:0.125 g/ time, twice daily, over 2 years old:0.25 g/time, twice daily. Both groups were treated for 4 to 7 days according to the improvement of the children's symptoms. After treatment, the total therapeutic efficiency, symptom improvement, changes of T cell subsets before and after treatment, and drug safety in two groups were compared. Results After treatment, the total effective rate in the observation group was 93.75%, significantly higher than 75.00% of the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the stool frequency and character score, and antidiarrhea time of the observation group were significantly lower than those of the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in two groups were significantly increased (P<0.05), and the Tlymphocyte subsets in the observation group were significantly higher than those in the control group (P<0.05). No adverse drug reactions occurred in two groups. Conclusion Saccharomyces boulardii sachets combined with Montmorillonite Powder can effectively relieve the symptoms of diarrhea, improve the immunity of children, and the efficacy is safe and reliable, which is worth popularizing and applying in the treatment of acute diarrhea in children.

R975

國(guó)家衛(wèi)生計(jì)生委醫(yī)藥衛(wèi)生科技發(fā)展項(xiàng)目（W2016EWAH07）