目的 研究艾迪注射液聯(lián)合鹽酸羥考酮緩釋片治療晚期胃癌癌痛的效果。方法 選擇2011年1月—2017年12月河南省許昌市立醫(yī)院收治的58例晚期胃癌患者作為研究對象，隨機將患者分為對照組和觀察組，每組各29例。對照組口服鹽酸羥考酮緩釋片，20 mg/次，1次/d。觀察組在對照組的基礎(chǔ)上靜脈滴注艾迪注射液，50 mL/次，1次/d。兩組均給藥7 d。觀察兩組治療后的止痛效果、體力狀態(tài)和不良反應(yīng)發(fā)生情況。結(jié)果 觀察組治療后的止痛有效率為93.10%，明顯高于對照組的79.31%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組治療后的體力狀態(tài)均有所緩解且保持穩(wěn)定，觀察組患者的體力狀態(tài)改善情況顯著優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療期間，觀察組的便秘、惡心嘔吐和頭暈乏力發(fā)生率均明顯低于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 艾迪注射液聯(lián)合鹽酸羥考酮緩釋片可有效地緩解晚期胃癌患者的癌痛，降低不良反應(yīng)的發(fā)生率，且能改善患者的體力狀態(tài)。

Objective To investigate the clinical effect of Aidi Injection combined with Oxycodone Hydrochloride Prolonged-release Tablets in treatment of cancer pain in advanced gastric cancer. Methods Patients (58 cases) with advanced gastric cancer in Xuchang Municipal Hospital from January 2011 to December 2017 were divided into control and observation groups randomly, each group had 29 cases. Patients in the control group were po administered with Oxycodone Hydrochloride Prolonged-release Tablets, 20 mg/time, once daily. Patients in the observation group were iv administered with Aidi Injection on the basis of control group, 50 mL/time, once daily. Patients in two groups were treated for 7 d. After treatment, the analgesic effect, physical state, and adverse reactions in two groups were observed. Results After treatment, the effective rate of analgesia in the observation group was 93.10%, which was significantly higher than 79.31% in the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the physical state in two groups was relieved and remained stable. The improvement of the physical state in the observation group was significantly better than that in the control group, and the difference between two groups was statistically significant (P<0.05). During the treatment, the incidence of constipation, nausea and vomiting, and dizziness and fatigue in the observation group were significantly lower than those in the control group, and the difference between two groups was statistically significant (P<0.05). Conclusion Aidi Injection combined with Oxycodone Hydrochloride Prolonged-release Tablets can effectively relieve the cancer pain of patients with advanced gastric cancer, reduce the incidence of adverse reactions, and improve the physical state of patients.

R979.1