注射用丹參多酚酸（SAFI）作為腦梗死的輔助治療藥，能有效改善神經(jīng)功能缺損癥狀，有效性和安全性已經(jīng)得到認(rèn)可。近年研究發(fā)現(xiàn)SAFI在神經(jīng)系統(tǒng)疾病中具有抗炎、抑制氧化應(yīng)激、抑制神經(jīng)細(xì)胞凋亡、拮抗缺血再灌注損傷、穩(wěn)定斑塊、改善認(rèn)知功能等作用。就近年來國內(nèi)外對SAFI在中樞神經(jīng)系統(tǒng)疾病中的藥理作用的研究進展進行綜述，為進一步深度研發(fā)和臨床合理應(yīng)用提供依據(jù)。

As an adjuvant therapy for cerebral infarction, Salvianolic Acid for Injection (SAFI) can effectively improve the symptoms of neurological deficit, and its efficacy and safety have been recognized. In recent years, studies have found that SAFI has the functions of anti-inflammatory, inhibiting oxidative stress, regulating apoptosis, antagonizing ischemia-reperfusion injury, stabilizing plaques, and improving cognitive in neurological diseases. In this paper, the research progress of the pharmacological effects of SAFI in central nervous system diseases at home and abroad are reviewed in recent years, providing a basis for further research and development and rational clinical application.

R286.1;R286.2

山西省自然科學(xué)基金（201801D121219）