苦參堿和氧化苦參堿能防治氧化偶氮甲烷/葡聚糖硫酸鈉誘發(fā)小鼠原發(fā)性結(jié)直腸癌和CT26細(xì)胞或SW480-EGFP細(xì)胞移植瘤在大鼠或小鼠體內(nèi)生長(zhǎng)。體外實(shí)驗(yàn)發(fā)現(xiàn)苦參堿和氧化苦參堿能濃度相關(guān)地抑制大腸癌SW480細(xì)胞、SW480-EGFP細(xì)胞、SW480/M5細(xì)胞、SW620細(xì)胞、SW1116細(xì)胞、LoVo細(xì)胞、HT-29細(xì)胞、Colon26細(xì)胞、HCT116細(xì)胞、HCT-8細(xì)胞、HCL細(xì)胞和LS174t細(xì)胞增殖，并誘導(dǎo)凋亡?？鄥A能增強(qiáng)奧沙利鉑抗SW480細(xì)胞、SW620細(xì)胞和SW1116細(xì)胞的作用。氧化苦參堿能增強(qiáng)5-氟尿嘧啶抗LoVo細(xì)胞的作用。

Matrine and oxymatrine have the effects in the prophylaxis and treatment of mice primary colorectal carcinoma induced by azoxymethane/dextran sulfate sodium and growth of transplantation tumor of large intestine carcinoma CT26 cells or SW480-EGFP cells in rats or mice. Matrine and oxymatrine inhibit proliferation and induce apoptosis in association with dosage on large intestine carcinoma SW480 cells, SW480-EGFP cells, SW480/M5 cells, SW620 cells, SW1116 cells, LoVo cells, HT-29 cells, Colon26 cells, HCT116 cells, HCT-8 cells, HCL cells, LS174t cells in vitro. Matrine can promote the effects of oxaliplatin against SW480 cells, SW620 cells, and SW1116 cells. Oxymatrine can promote the effect of fluorouracil against LoVo cells.

R285.6;R286.5