[關(guān)鍵詞]
[摘要]
目的 探討醒脾養(yǎng)兒顆粒聯(lián)合孟魯司特鈉對牛奶蛋白過敏患兒的臨床療效。方法 選擇2017年1月—12月在成都市龍泉驛區(qū)婦幼保健院診治的牛奶蛋白過敏患兒130例作為研究對象,根據(jù)隨機數(shù)字表法分為對照組與觀察組,每組各65例。對照組口服孟魯司特鈉咀嚼片,1~4歲患兒4 mg,≥5歲患兒5 mg,臨睡前服用,1次/d,持續(xù)應(yīng)用1個月。觀察組在對照組治療的基礎(chǔ)上以溫水沖服醒脾養(yǎng)兒顆粒,2~4 g/次,1次/d,治療觀察1個月。觀察兩組患兒的臨床療效,同時比較兩組治療前后的皮膚指數(shù)(SI)值、免疫功能指標(biāo)和炎癥因子指標(biāo)。結(jié)果 治療后,觀察組治療的總有效率為96.9%,顯著高于對照組的84.6%(P<0.05)。治療后,兩組的牛奶蛋白SI值顯著降低(P<0.05);且觀察組SI值顯著低于對照組(P<0.05)。兩組治療后的免疫球蛋白IgM、IgG與IgA值顯著高于治療前(P<0.05);且觀察組IgM、IgG與IgA值顯著高于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。兩組治療后的血清腫瘤壞死因子-α(TNF-α)、白細(xì)胞介素-6(IL-6)水平均顯著降低(P<0.05);且治療后,觀察組炎癥反應(yīng)因子水平顯著低于對照組,(P<0.05)。結(jié)論 醒脾養(yǎng)兒顆粒聯(lián)合孟魯司特鈉在牛奶蛋白過敏患兒中的應(yīng)用能抑制炎癥反應(yīng),提高患兒的免疫功能,從而改善患兒的預(yù)后。
[Key word]
[Abstract]
Objective To investigate the effects of Xingpi Yanger Granules combined with montelukast sodium in treatment of milk protein allergy in children. Methods Children (130 cases) with milk protein allergy in Longquanyi District of Chengdu Maternity and Child Health Care Hospital from January 2017 to December 2017 were selected as subjects, and were equally divided into the control and observation group, each group had 65 cases. Children in the control group were po administered with Montelukast Sodium Chewable Tablets, 4 mg for children aged 1-4 years, and 5 mg for children aged more than 5 years, and took them before going to bed once daily. Children in the observation group were po administered with Xingpi Yanger Granules on the basis of control group, 2-4 g/time, once daily by warm water. Both groups were treated for 1 month. The clinical efficacy in two groups was observed, and the SI, immune function and inflammatory factors before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 96.9%, significantly higher than 84.6% of the control group (P<0.05). After treatment, SI values in both groups were significantly decreased (P<0.05). And the SI value of the observation group was significantly lower than that of the control group (P<0.05). After treatment, IgM, IgG and IgA in the two groups were significantly higher than those before treatment (P<0.05). After treatment, IgM, IgG, and IgA values of the observation group were significantly higher than those of the control group (P<0.05). After treatment, the levels of TNF-α, IL-6 in two groups were significantly decreased (P<0.05). After treatment, the inflammatory factor level in the observation group was significantly lower than those of the control group (P<0.05). Conclusion The application of Xingpi Yanger Granules combined with montelukast sodium in children with milk protein allergy can inhibit inflammation, improve immune function and improve prognosis of children.
[中圖分類號]
R985
[基金項目]
國家衛(wèi)生計生委醫(yī)藥衛(wèi)生科技發(fā)展研究中心項目(W2015EAE176)