目的 探討麝香保心丸聯(lián)合阿托伐他汀鈣對(duì)心絞痛患者治療效果、血脂水平及血清學(xué)指標(biāo)的影響。方法 選取2016年12月—2018年12月滁州市第一人民醫(yī)院74例心絞痛患者為研究對(duì)象，根據(jù)入院?jiǎn)坞p號(hào)將患者分為對(duì)照組和觀察組，每組各37例。對(duì)照組患者口服阿托伐他汀鈣片，20 mg/次，1次/d。觀察組患者在對(duì)照組的基礎(chǔ)上口服麝香保心丸，45 mg/次，3次/d。兩組均連續(xù)治療2個(gè)月。觀察兩組患者的臨床療效，同時(shí)比較兩組治療前后的癥狀改善情況、血脂及血清學(xué)指標(biāo)。結(jié)果 治療后，對(duì)照組和觀察組的總有效率分別為75.68%、94.59%，兩組比較存在統(tǒng)計(jì)學(xué)差異（P<0.05）。治療后，兩組患者胸痛發(fā)作時(shí)間顯著縮短，心絞痛發(fā)作次數(shù)顯著減少（P<0.05），且觀察組癥狀改善情況顯著優(yōu)于對(duì)照組（P<0.05）。治療后，兩組患者高密度脂蛋白膽固醇（HDL-C）顯著升高，低密度脂蛋白膽固醇（LDL-C）、三酰甘油（TG）和總膽固醇（TC）水平均明顯降低（P<0.05）；且觀察組各血脂指標(biāo)水平顯著優(yōu)于對(duì)照組（P<0.05）。治療后，兩組患者同型半胱氨酸（Hcy）、超敏C反應(yīng)蛋白（hs-CRP）水平均明顯降低（P<0.05），且觀察組Hcy、hs-CRP水平顯著低于對(duì)照組（P<0.05）。結(jié)論 麝香保心丸聯(lián)合阿托伐他汀鈣可有效改善患者的臨床癥狀，改善血脂及血清Hcy、hs-CRP水平，療效確切，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore effect of Shexiang Baoxin Pills on therapeutic effect, blood lipid levels, and serological index in patients with angina pectoris. Methods Patients (74 cases) with angina pectoris in THE First People's Hospital of Chuzhou from December 2016 to December 2018 were selected as the research objects, and the patients were divided into control group and observation group according to the odd-even number of admission, 37 patients in each group. Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the observation group were po administered with Shexiang Baoxin Pills on the basis of control group, 45 mg/time, three times daily. Both groups were treated continuously for 2 months. After treatment, the clinical efficacy in two groups was observed, and the symptom improvement, blood lipid and serological indexes before and after treatment were compared. Results After treatment, the total effective rate of the control group and the observation group was 75.68% and 94.59%, respectively, with statistical difference between the two groups (P<0.05). After treatment, the duration of chest pain and the number of angina attacks in two groups were significantly shortened (P<0.05), and the symptom improvement in the observation group was significantly better than that in the control group (P<0.05). After treatment, HDL-C level in two groups was significantly increased, but the levels of LDL-C, TG, and TC were significantly decreased (P<0.05). And the levels of serum lipid in the observation group were significantly better than those in the control group (P<0.05). After treatment, the levels of Hcy and hs-CRP in two groups were significantly decreased (P<0.05), and the levels of Hcy and hs-CRP in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Shexiang Baoxin Pills combined with atorvastatin calcium can effectively improve the clinical symptoms of patients, improve blood lipid, serum Hcy and hs-CRP levels, it has certain clinical application value.

R972

滁州市科技計(jì)劃項(xiàng)目（201346）