目的 探討熱毒寧注射液聯(lián)合消旋卡多曲治療小兒病毒性腸炎的臨床療效。方法 選擇2017年12月—2018年12月陜西中醫(yī)藥大學附屬醫(yī)院治療的120例病毒性腸炎患兒為研究對象。將患兒隨機分為對照組和觀察組，每組各60例。對照組口服消旋卡多曲顆粒，1.5 mg/kg，3次/d，連續(xù)服用3 d。觀察組在對照組的基礎上靜脈滴注熱毒寧注射液于100 mL生理鹽水中稀釋，0.6 mL/（kg·d），1次/d，連續(xù)治療3 d。觀察兩組患者的臨床療效，同時比較兩組治療前后的臨床癥狀評分和炎性因子水平。結果 治療后，觀察組總有效率為96.67%，顯著高于對照組的85.00%（P<0.05）。治療后，兩組惡心嘔吐、大便異常、腹痛和腹瀉評分均顯著下降（P<0.05），且觀察組各臨床癥狀積分均顯著低于對照組（P<0.05）。治療后，兩組患兒白細胞介素-6（IL-6）、C反應蛋白（CRP）和腫瘤壞死因子-α（TNF-α）水平均顯著下降（P<0.05），且觀察組治療后炎性因子水平顯著低于對照組（P<0.05）。結論 熱毒寧注射液聯(lián)合消旋卡多曲治療小兒病毒性腸炎的效果顯著，可顯著降低患兒的炎性因子水平，具有一定的臨床推廣價值。

Objective To investigate the effect of Reduning Injection combined with racecadotril in treatment of viral enteritis. Methods Children (120 cases) with viral enteritis in the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from December 2017 to December 2018 were selected as study subjects. Children were randomly divided into control group and observation group with 60 cases in each group. Children in the control group were po administered with Racecadotril Granules, 1.5 mg/kg, three times daily. Children in the observation group were iv administered with Reduning Injection on the basis of control group, diluted in 100 mL normal saline, 0.6 mL/(kg·d), once daily. Children in two groups were treated consecutively for 3 days. The clinical efficacy in two groups was observed, and the clinical symptom scores and inflammatory factor levels in two groups were compared before and after treatment. Results After treatment, the total effective rate of the observation group was 96.67%, which was significantly higher than 85.00% of the control group (P<0.05). After treatment, scores of nausea and vomiting, abnormal stool, abdominal pain, and diarrhea in two groups were significantly decreased (P<0.05), and scores of clinical symptoms in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of IL-6, CRP and TNF-α in two groups were significantly decreased (P<0.05), and the levels of inflammatory factors in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Reduning Injection combined with racecadotril has a remarkable effect in treatment of viral enteritis in children, and can significantly reduce the level of inflammatory factors in children, it has certain clinical promotion value.

R975

陜西省社會發(fā)展科技攻關項目（2015SF203）