目的 探討丹參注射液聯(lián)合孟魯司特鈉對過敏性紫癜患兒免疫學(xué)指標和炎癥因子的影響。方法 選取2016年11月—2018年11月安陽市中醫(yī)院90例過敏性紫癜患兒為研究對象，根據(jù)就診順序均分為對照組（n=45）和觀察組（n=45）。對照組在此基礎(chǔ)上口服孟魯司特鈉咀嚼片，3～6歲：4 mg/次，1次/d，6～14歲：5 mg/次，1次/d。觀察組患兒在對照組的基礎(chǔ)上靜脈滴注丹參注射液，0.5 mL/（kg·d），加入到5%葡萄糖溶液250 mL中，每日不超過20 mL。兩組患者均連續(xù)治療2周。觀察兩組患者的臨床療效，同時比較兩組治療前后的血清免疫學(xué)指標和炎癥因子水平。結(jié)果 治療后，觀察組患兒治療總有效率為95.56%，對照組總有效率為77.78%，兩組比較差異性顯著（P<0.05）。治療后，兩組患者免疫球蛋白（Ig）A、IgE、補體C3水平均較治療前明顯降低（P<0.05），且觀察組IgA、IgE和補體C3水平顯著低于對照組（P<0.05）。治療后兩組患者白細胞介素-6（IL-6）、白細胞介素-8（IL-8）、白細胞介素-26（IL-26）和腫瘤細胞壞死因子-α（TNF-α）水平較治療前均顯著降低（P<0.05），且觀察組細胞因子水平顯著低于對照組（P<0.05）。結(jié)論 丹參注射液聯(lián)合孟魯司特鈉可有效減輕血液系統(tǒng)炎性反應(yīng)，調(diào)節(jié)免疫，臨床療效顯著，在過敏性紫癜患兒治療中具有較高的應(yīng)用價值。

Objective To explore effect of Danshen Injection combined with montelukast sodium on serum immunological indicators and inflammatory factors in children with allergic purpura. Methods A total of 90 children with allergic purpura in Anyang Chinese Medicine Hospital from November 2016 to November 2018 were selected as research objects, and were divided into control group (n=45) and observation group (n=45) according to the order of treatment. Children in the control group po administered with Montelukast Sodium Chewable Tablets, 3 to 6 years old:4 mg/time, once daily, 6 to 14 years old:5 mg/time, once daily. Children in the observation group were iv administered with Danshen Injection on the basis of control group, 0.5 mL/(kg·d), which was added to 5% glucose solution 250 mL, no more than 20 mL per day. Patients in both groups were treated continuously for 2 weeks. The clinical efficacy in two groups was observed, and the serum immunological indexes and inflammatory factors before and after treatment were compared. Results After treatment, the total effective rate was 95.56% in the observation group and 77.78% in the control group, with significant difference between the two groups (P<0.05). After treatment, the levels of IgA, IgE, and C3 in two groups were significantly lower than those before treatment (P<0.05), and the levels of IgA, IgE, and C3 in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of IL-6, IL-8, IL-26, and TNF-α in two groups were significantly lower than those before treatment (P<0.05), and the levels of cytokines in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Danshen Injection combined with montelukast sodium can effectively reduce the inflammatory response, and regulate the immune system, with significant clinical efficacy, and has high application value in the treatment of children with allergic purpura.

R979.5

安陽市重點科技計劃項目（2015-95）